Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection

Theophilus S. Vijaykumar, Avindra Nath, Ashok Chauhan

Research output: Contribution to journalArticlepeer-review

Abstract

We report in this study that minimum productive HIV infection in astrocytes (a predominant cell type in brain and persists for the entire life) occurs through endocytosis. The lysosomotropic agent chloroquine enhanced permissiveness of astrocytes to HIV infection possibly by circumventing degradation of endosome-entrapped viral particles. In particular, chloroquine may promote establishment of a stable long term viral reservoir in astrocytes and may eventually facilitate early onset of neurological complications.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalVirology
Volume381
Issue number1
DOIs
StatePublished - Nov 10 2008

Keywords

  • HIV-astrocyte
  • HIV-reservoir
  • Lysosomotropic agents

ASJC Scopus subject areas

  • Virology

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