Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection

Theophilus S. Vijaykumar; Avindra Nath; Ashok Chauhan

doi:10.1016/j.virol.2008.07.039

Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection

Theophilus S. Vijaykumar, Avindra Nath, Ashok Chauhan

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

We report in this study that minimum productive HIV infection in astrocytes (a predominant cell type in brain and persists for the entire life) occurs through endocytosis. The lysosomotropic agent chloroquine enhanced permissiveness of astrocytes to HIV infection possibly by circumventing degradation of endosome-entrapped viral particles. In particular, chloroquine may promote establishment of a stable long term viral reservoir in astrocytes and may eventually facilitate early onset of neurological complications.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Virology
Volume	381
Issue number	1
DOIs	https://doi.org/10.1016/j.virol.2008.07.039
State	Published - Nov 10 2008
Externally published	Yes

Keywords

HIV-astrocyte
HIV-reservoir
Lysosomotropic agents

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2008.07.039

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title = "Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection",

abstract = "We report in this study that minimum productive HIV infection in astrocytes (a predominant cell type in brain and persists for the entire life) occurs through endocytosis. The lysosomotropic agent chloroquine enhanced permissiveness of astrocytes to HIV infection possibly by circumventing degradation of endosome-entrapped viral particles. In particular, chloroquine may promote establishment of a stable long term viral reservoir in astrocytes and may eventually facilitate early onset of neurological complications.",

keywords = "HIV-astrocyte, HIV-reservoir, Lysosomotropic agents",

author = "Vijaykumar, {Theophilus S.} and Avindra Nath and Ashok Chauhan",

note = "Funding Information: We thank Drs. D. Levy (New York University) for NLENY1 and NLENV3Y1constructs and J. Patton (University of South Carolina) for the discussions. This study was funded by NIH-grants R01NS050064 to AC and P01MH070306 to AN.",

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AU - Vijaykumar, Theophilus S.

AU - Nath, Avindra

AU - Chauhan, Ashok

N1 - Funding Information: We thank Drs. D. Levy (New York University) for NLENY1 and NLENV3Y1constructs and J. Patton (University of South Carolina) for the discussions. This study was funded by NIH-grants R01NS050064 to AC and P01MH070306 to AN.

PY - 2008/11/10

Y1 - 2008/11/10

N2 - We report in this study that minimum productive HIV infection in astrocytes (a predominant cell type in brain and persists for the entire life) occurs through endocytosis. The lysosomotropic agent chloroquine enhanced permissiveness of astrocytes to HIV infection possibly by circumventing degradation of endosome-entrapped viral particles. In particular, chloroquine may promote establishment of a stable long term viral reservoir in astrocytes and may eventually facilitate early onset of neurological complications.

AB - We report in this study that minimum productive HIV infection in astrocytes (a predominant cell type in brain and persists for the entire life) occurs through endocytosis. The lysosomotropic agent chloroquine enhanced permissiveness of astrocytes to HIV infection possibly by circumventing degradation of endosome-entrapped viral particles. In particular, chloroquine may promote establishment of a stable long term viral reservoir in astrocytes and may eventually facilitate early onset of neurological complications.

KW - HIV-astrocyte

KW - HIV-reservoir

KW - Lysosomotropic agents

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Chloroquine mediated molecular tuning of astrocytes for enhanced permissiveness to HIV infection

Abstract

Keywords

ASJC Scopus subject areas

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