Chloroquine does not enhance the activity of clarithromycin against multiplication of Mycobacterium avium within human macrophages

T. Lazard, C. Perronne, C. Truffot-Pernot, J. Grosset, J. L. Vildé, J. J. Pocidalo

Research output: Contribution to journalArticle

Abstract

Setting: Chloroquine, an alkalinizing lysosomotropic agent, enhances the intracellular activity of antibiotics against Mycobacterium tuberculosis or Coxiella burnetii. Objective: To determine if chloroquine modifies the activity of clarithromycin, less effective at acidic pH, against intracellular Mycobacterium avium. Design: The activity of clarithromycin (4 μg/ml) against the MO-1 strain of M. avium was evaluated within human macrophages in presence of chloroquine (5 μg/ml). The minimal inhibitory concentration of clarithromycin for the strain was 2 μg/ml. Results: While clarithromycin alone did decrease the intracellular infection at day 7 of culture (P < 0.01), chloroquine alone did not impede the intracellular growth of M. avium, and did not enhance the activity of clarithromycin. Conclusion: Chloroquine should not improve clarithromycin treatment against M. avium infection.

Original languageEnglish (US)
Pages (from-to)283-285
Number of pages3
JournalTubercle and Lung Disease
Volume75
Issue number4
DOIs
StatePublished - Aug 1994

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Pulmonary and Respiratory Medicine

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