The widespread use of chloramphenicol in the newborn infant prior to an adequate appreciation of the special characteristics of the mechanism of action of the drug in the neonate led to the tragic saga of the gray syndrom. Some 20 years later, we possess considerably more insight into the effects of chloramphenicol and the handling of the drug by the newborn infant. This insight should allow for the use of this potentially valuable drug in a safe and effective manner. The availability of sensitive and specific assays for chloramphenicol makes therapeutic monitoring feasible and such monitoring should add to the safety of the use of chloramphenicol in the newborn infant.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynecology