Ten patients with Behcet's disease were treated with chlorambucil alone. At the therapeutic drug level of 0.2 mg/kg, seven patients developed oligospermia and three patients developed azoospermia. A 30-year-old patient underwent a testicular biopsy two years after the cessation of therapy. Histopathology revealed evidence of testicular atrophy. Fifteen (75%) out of 20 eyes had a visual acuity of 20/200 or less following therapy. It is concluded that chlorambucil should not be used as the first line of therapy in Behcet's disease and that its long term benefits in patients with Behcet's disease should be reevaluated.
|Original language||English (US)|
|Number of pages||3|
|State||Published - 1983|
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