Chlamydia pneumoniae infection and risk of lung cancer

Alyson J. Littman, Emily White, Lisa A. Jackson, Mark D. Thornquist, Charlotte A Gaydos, Gary E. Goodman, Thomas L. Vaughan

Research output: Contribution to journalArticle

Abstract

Infection with Chlamydia pneumoniae may be associated with an increased risk of lung cancer. We conducted a matched case-control study (508 pairs) nested within a large prospective study to investigate whether IgA antibody titers to C. pneumoniae measured by the microimmunofluorescence test are associated with lung cancer risk after controlling for confounders. Individuals with antibody titers ≥16 had 1.2 times the risk of lung cancer (95% confidence interval, 0.9-1.6) compared to those with lower titers. There was a significant trend (P = 0.007) of increasing odds ratios with increasing IgA titers primarily due to an odds ratio of 2.8 (95% confidence interval, 1.1-6.7) associated with titers ≥256. Lung cancer risk associated with IgA titers ≥16 was stronger among former smokers. To better understand predictors of IgA seropositivity, we also examined demographic, lifestyle, dietary, and medical correlates of IgA titers ≥16 among controls. Those with race not classified as White or Black were more likely to have IgA titers ≥16; there were no significant differences in seropositivity by smoking behaviors. In summary, the adjusted odds ratio for lung cancer associated with IgA titers ≥16 was compatible with a weakly positive association, although nondifferential measurement error of antibody titers may have resulted in a conservative bias. Future studies using precise measures of chronic C. pneumoniae status are needed to better determine the role of this organism in the etiology of lung cancer.

Original languageEnglish (US)
Pages (from-to)1624-1630
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume13
Issue number10
StatePublished - Oct 2004

Fingerprint

Chlamydophila pneumoniae
Chlamydia Infections
Immunoglobulin A
Lung Neoplasms
Odds Ratio
Antibodies
Confidence Intervals
Case-Control Studies
Life Style
Smoking
Demography
Prospective Studies
Infection

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Littman, A. J., White, E., Jackson, L. A., Thornquist, M. D., Gaydos, C. A., Goodman, G. E., & Vaughan, T. L. (2004). Chlamydia pneumoniae infection and risk of lung cancer. Cancer Epidemiology Biomarkers and Prevention, 13(10), 1624-1630.

Chlamydia pneumoniae infection and risk of lung cancer. / Littman, Alyson J.; White, Emily; Jackson, Lisa A.; Thornquist, Mark D.; Gaydos, Charlotte A; Goodman, Gary E.; Vaughan, Thomas L.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 13, No. 10, 10.2004, p. 1624-1630.

Research output: Contribution to journalArticle

Littman, AJ, White, E, Jackson, LA, Thornquist, MD, Gaydos, CA, Goodman, GE & Vaughan, TL 2004, 'Chlamydia pneumoniae infection and risk of lung cancer', Cancer Epidemiology Biomarkers and Prevention, vol. 13, no. 10, pp. 1624-1630.
Littman AJ, White E, Jackson LA, Thornquist MD, Gaydos CA, Goodman GE et al. Chlamydia pneumoniae infection and risk of lung cancer. Cancer Epidemiology Biomarkers and Prevention. 2004 Oct;13(10):1624-1630.
Littman, Alyson J. ; White, Emily ; Jackson, Lisa A. ; Thornquist, Mark D. ; Gaydos, Charlotte A ; Goodman, Gary E. ; Vaughan, Thomas L. / Chlamydia pneumoniae infection and risk of lung cancer. In: Cancer Epidemiology Biomarkers and Prevention. 2004 ; Vol. 13, No. 10. pp. 1624-1630.
@article{3e228c6b15114a77b4d38a91a4d309a2,
title = "Chlamydia pneumoniae infection and risk of lung cancer",
abstract = "Infection with Chlamydia pneumoniae may be associated with an increased risk of lung cancer. We conducted a matched case-control study (508 pairs) nested within a large prospective study to investigate whether IgA antibody titers to C. pneumoniae measured by the microimmunofluorescence test are associated with lung cancer risk after controlling for confounders. Individuals with antibody titers ≥16 had 1.2 times the risk of lung cancer (95{\%} confidence interval, 0.9-1.6) compared to those with lower titers. There was a significant trend (P = 0.007) of increasing odds ratios with increasing IgA titers primarily due to an odds ratio of 2.8 (95{\%} confidence interval, 1.1-6.7) associated with titers ≥256. Lung cancer risk associated with IgA titers ≥16 was stronger among former smokers. To better understand predictors of IgA seropositivity, we also examined demographic, lifestyle, dietary, and medical correlates of IgA titers ≥16 among controls. Those with race not classified as White or Black were more likely to have IgA titers ≥16; there were no significant differences in seropositivity by smoking behaviors. In summary, the adjusted odds ratio for lung cancer associated with IgA titers ≥16 was compatible with a weakly positive association, although nondifferential measurement error of antibody titers may have resulted in a conservative bias. Future studies using precise measures of chronic C. pneumoniae status are needed to better determine the role of this organism in the etiology of lung cancer.",
author = "Littman, {Alyson J.} and Emily White and Jackson, {Lisa A.} and Thornquist, {Mark D.} and Gaydos, {Charlotte A} and Goodman, {Gary E.} and Vaughan, {Thomas L.}",
year = "2004",
month = "10",
language = "English (US)",
volume = "13",
pages = "1624--1630",
journal = "Cancer Epidemiology Biomarkers and Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "10",

}

TY - JOUR

T1 - Chlamydia pneumoniae infection and risk of lung cancer

AU - Littman, Alyson J.

AU - White, Emily

AU - Jackson, Lisa A.

AU - Thornquist, Mark D.

AU - Gaydos, Charlotte A

AU - Goodman, Gary E.

AU - Vaughan, Thomas L.

PY - 2004/10

Y1 - 2004/10

N2 - Infection with Chlamydia pneumoniae may be associated with an increased risk of lung cancer. We conducted a matched case-control study (508 pairs) nested within a large prospective study to investigate whether IgA antibody titers to C. pneumoniae measured by the microimmunofluorescence test are associated with lung cancer risk after controlling for confounders. Individuals with antibody titers ≥16 had 1.2 times the risk of lung cancer (95% confidence interval, 0.9-1.6) compared to those with lower titers. There was a significant trend (P = 0.007) of increasing odds ratios with increasing IgA titers primarily due to an odds ratio of 2.8 (95% confidence interval, 1.1-6.7) associated with titers ≥256. Lung cancer risk associated with IgA titers ≥16 was stronger among former smokers. To better understand predictors of IgA seropositivity, we also examined demographic, lifestyle, dietary, and medical correlates of IgA titers ≥16 among controls. Those with race not classified as White or Black were more likely to have IgA titers ≥16; there were no significant differences in seropositivity by smoking behaviors. In summary, the adjusted odds ratio for lung cancer associated with IgA titers ≥16 was compatible with a weakly positive association, although nondifferential measurement error of antibody titers may have resulted in a conservative bias. Future studies using precise measures of chronic C. pneumoniae status are needed to better determine the role of this organism in the etiology of lung cancer.

AB - Infection with Chlamydia pneumoniae may be associated with an increased risk of lung cancer. We conducted a matched case-control study (508 pairs) nested within a large prospective study to investigate whether IgA antibody titers to C. pneumoniae measured by the microimmunofluorescence test are associated with lung cancer risk after controlling for confounders. Individuals with antibody titers ≥16 had 1.2 times the risk of lung cancer (95% confidence interval, 0.9-1.6) compared to those with lower titers. There was a significant trend (P = 0.007) of increasing odds ratios with increasing IgA titers primarily due to an odds ratio of 2.8 (95% confidence interval, 1.1-6.7) associated with titers ≥256. Lung cancer risk associated with IgA titers ≥16 was stronger among former smokers. To better understand predictors of IgA seropositivity, we also examined demographic, lifestyle, dietary, and medical correlates of IgA titers ≥16 among controls. Those with race not classified as White or Black were more likely to have IgA titers ≥16; there were no significant differences in seropositivity by smoking behaviors. In summary, the adjusted odds ratio for lung cancer associated with IgA titers ≥16 was compatible with a weakly positive association, although nondifferential measurement error of antibody titers may have resulted in a conservative bias. Future studies using precise measures of chronic C. pneumoniae status are needed to better determine the role of this organism in the etiology of lung cancer.

UR - http://www.scopus.com/inward/record.url?scp=4944235676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4944235676&partnerID=8YFLogxK

M3 - Article

C2 - 15466979

AN - SCOPUS:4944235676

VL - 13

SP - 1624

EP - 1630

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

IS - 10

ER -