Chk1 phosphorylation during mitosis: A new role for a master regulator

Deborah Wilsker, Fred Bunz

Research output: Contribution to journalReview article

Abstract

The human DNA damage responses are modulated by both nonessential and essential pathways. The extensively studied ATM kinase and p53 are examples of the former. While loss-of-function mutations in genes that encode ATM and p53 cause marked predispositions to cancer, the loss of these proteins does not appear to impact basic cell growth and proliferation. In contrast, the checkpoint kinase Chk1 and its upstream activator ATR are essential. 1-4 What do these proteins do in undamaged cells?

Original languageEnglish (US)
Pages (from-to)1161-1163
Number of pages3
JournalCell Cycle
Volume8
Issue number8
DOIs
StatePublished - Apr 15 2009

Keywords

  • ATR
  • Cell cycle
  • Chk1
  • Ionizing radiation
  • Mitosis
  • Phosphorylation

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Chk1 phosphorylation during mitosis: A new role for a master regulator'. Together they form a unique fingerprint.

Cite this