Chk1 phosphorylation during mitosis: A new role for a master regulator

Deborah Wilsker, Fred Bunz

Research output: Contribution to journalArticle

Abstract

The human DNA damage responses are modulated by both nonessential and essential pathways. The extensively studied ATM kinase and p53 are examples of the former. While loss-of-function mutations in genes that encode ATM and p53 cause marked predispositions to cancer, the loss of these proteins does not appear to impact basic cell growth and proliferation. In contrast, the checkpoint kinase Chk1 and its upstream activator ATR are essential. 1-4 What do these proteins do in undamaged cells?

Original languageEnglish (US)
Pages (from-to)1161-1163
Number of pages3
JournalCell cycle (Georgetown, Tex.)
Volume8
Issue number8
StatePublished - Apr 15 2009

Fingerprint

Mitosis
Phosphorylation
DNA Damage
Proteins
Phosphotransferases
Cell Proliferation
Mutation
Growth
Genes
Neoplasms
Checkpoint Kinase 1

Keywords

  • ATR
  • Cell cycle
  • Chk1
  • Ionizing radiation
  • Mitosis
  • Phosphorylation

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Cite this

Chk1 phosphorylation during mitosis : A new role for a master regulator. / Wilsker, Deborah; Bunz, Fred.

In: Cell cycle (Georgetown, Tex.), Vol. 8, No. 8, 15.04.2009, p. 1161-1163.

Research output: Contribution to journalArticle

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