Chiral recognition of functionalized cyclodextrins in capillary electrophoresis

Karen W. Phinney, John W. Jackson, Lane C. Sander

Research output: Contribution to journalArticle

Abstract

The chiral recognition of hydroxypropylated, dimethylated, and sulfated cyclodextrins was evaluated by utilizing them as chiral additives in capillary electrophoresis. Although each selector yielded enantiomeric separations of most of the target analytes, differences were observed in the electrophoretic results for the different derivatized cyclodextrins and for additives having varying degrees of substitution. The results for the sulfated cyclodextrins also highlighted the importance of knowing the degree of substitution as well as the location of the substituents when comparing chiral selectors.

Original languageEnglish (US)
Pages (from-to)1308-1313
Number of pages6
JournalELECTROPHORESIS
Volume23
Issue number9
DOIs
StatePublished - Jun 10 2002
Externally publishedYes

Keywords

  • Capillary electrophoresis
  • Chiral recognition
  • Cyclodextrins
  • Enantiomers

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

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