Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge

Daphne A. Stanley, Anna N. Honko, Clement Asiedu, John C. Trefry, Annie W. Lau-Kilby, Joshua C. Johnson, Lisa Hensley, Virginia Ammendola, Adele Abbate, Fabiana Grazioli, Kathryn E. Foulds, Cheng Cheng, Lingshu Wang, Mitzi M. Donaldson, Stefano Colloca, Antonella Folgori, Mario Roederer, Gary J. Nabel, John Mascola, Alfredo NicosiaRiccardo Cortese, Richard A. Koup, Nancy J. Sullivan

Research output: Contribution to journalArticle

Abstract

Ebolavirus disease causes high mortality, and the current outbreak has spread unabated through West Africa. Human adenovirus type 5 vectors (rAd5) encoding ebolavirus glycoprotein (GP) generate protective immunity against acute lethal Zaire ebolavirus (EBOV) challenge in macaques, but fail to protect animals immune to Ad5, suggesting natural Ad5 exposure may limit vaccine efficacy in humans. Here we show that a chimpanzee-derived replication-defective adenovirus (ChAd) vaccine also rapidly induced uniform protection against acute lethal EBOV challenge in macaques. Because protection waned over several months, we boosted ChAd3 with modified vaccinia Ankara (MVA) and generated, for the first time, durable protection against lethal EBOV challenge.

Original languageEnglish (US)
Pages (from-to)1126-1129
Number of pages4
JournalNature Medicine
Volume20
Issue number10
DOIs
StatePublished - Oct 1 2014
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Stanley, D. A., Honko, A. N., Asiedu, C., Trefry, J. C., Lau-Kilby, A. W., Johnson, J. C., Hensley, L., Ammendola, V., Abbate, A., Grazioli, F., Foulds, K. E., Cheng, C., Wang, L., Donaldson, M. M., Colloca, S., Folgori, A., Roederer, M., Nabel, G. J., Mascola, J., ... Sullivan, N. J. (2014). Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge. Nature Medicine, 20(10), 1126-1129. https://doi.org/10.1038/nm.3702