Chimerism, Transplant Tolerance, and Beyond

Franka Messner, Joanna W. Etra, Jeffrey M Dodd-o, Gerald Brandacher

Research output: Contribution to journalArticle

Abstract

The present review discusses current developments in tolerance induction for solid organ transplantation with a particular emphasis on chimerism-based approaches. It explains the basic mechanisms of chimerism-based tolerance and provides an update on ongoing clinical tolerance trials. The concept of "delayed tolerance" is presented, and ongoing preclinical studies in the nonhuman primate setting-including current limitations and hurdles regarding this approach-are illustrated. In addition, a brief overview and update on cell-based tolerogenic clinical trials is provided. In a critical approach, advantages, limitations, and potential implications for the future of these different regimens are discussed.

Original languageEnglish (US)
Pages (from-to)1556-1567
Number of pages12
JournalTransplantation
Volume103
Issue number8
DOIs
StatePublished - Aug 1 2019

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Chimerism
Clinical Trials
Transplants
Organ Transplantation
Primates

ASJC Scopus subject areas

  • Transplantation

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Chimerism, Transplant Tolerance, and Beyond. / Messner, Franka; Etra, Joanna W.; Dodd-o, Jeffrey M; Brandacher, Gerald.

In: Transplantation, Vol. 103, No. 8, 01.08.2019, p. 1556-1567.

Research output: Contribution to journalArticle

Messner, Franka ; Etra, Joanna W. ; Dodd-o, Jeffrey M ; Brandacher, Gerald. / Chimerism, Transplant Tolerance, and Beyond. In: Transplantation. 2019 ; Vol. 103, No. 8. pp. 1556-1567.
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