Chimerism, transplant tolerance, and beyond

Franka Messner; Joanna W. Etra; Jeffrey M. Dodd-O; Gerald Brandacher

doi:10.1097/TP.0000000000002711

Chimerism, transplant tolerance, and beyond

Franka Messner, Joanna W. Etra, Jeffrey M. Dodd-O, Gerald Brandacher

School of Medicine

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

The present review discusses current developments in tolerance induction for solid organ transplantation with a particular emphasis on chimerism-based approaches. It explains the basic mechanisms of chimerism-based tolerance and provides an update on ongoing clinical tolerance trials. The concept of "delayed tolerance" is presented, and ongoing preclinical studies in the nonhuman primate setting-including current limitations and hurdles regarding this approach-Are illustrated. In addition, a brief overview and update on cell-based tolerogenic clinical trials is provided. In a critical approach, advantages, limitations, and potential implications for the future of these different regimens are discussed.

Original language	English (US)
Pages (from-to)	1556-1567
Number of pages	12
Journal	Transplantation
Volume	103
Issue number	8
DOIs	https://doi.org/10.1097/TP.0000000000002711
State	Published - Aug 1 2019

ASJC Scopus subject areas

Transplantation

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10.1097/TP.0000000000002711

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title = "Chimerism, transplant tolerance, and beyond",

abstract = "The present review discusses current developments in tolerance induction for solid organ transplantation with a particular emphasis on chimerism-based approaches. It explains the basic mechanisms of chimerism-based tolerance and provides an update on ongoing clinical tolerance trials. The concept of {"}delayed tolerance{"} is presented, and ongoing preclinical studies in the nonhuman primate setting-including current limitations and hurdles regarding this approach-Are illustrated. In addition, a brief overview and update on cell-based tolerogenic clinical trials is provided. In a critical approach, advantages, limitations, and potential implications for the future of these different regimens are discussed.",

author = "Franka Messner and Etra, {Joanna W.} and Dodd-O, {Jeffrey M.} and Gerald Brandacher",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 Wolters Kluwer Health, Inc.",

year = "2019",

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AU - Messner, Franka

AU - Etra, Joanna W.

AU - Dodd-O, Jeffrey M.

AU - Brandacher, Gerald

PY - 2019/8/1

Y1 - 2019/8/1

N2 - The present review discusses current developments in tolerance induction for solid organ transplantation with a particular emphasis on chimerism-based approaches. It explains the basic mechanisms of chimerism-based tolerance and provides an update on ongoing clinical tolerance trials. The concept of "delayed tolerance" is presented, and ongoing preclinical studies in the nonhuman primate setting-including current limitations and hurdles regarding this approach-Are illustrated. In addition, a brief overview and update on cell-based tolerogenic clinical trials is provided. In a critical approach, advantages, limitations, and potential implications for the future of these different regimens are discussed.

AB - The present review discusses current developments in tolerance induction for solid organ transplantation with a particular emphasis on chimerism-based approaches. It explains the basic mechanisms of chimerism-based tolerance and provides an update on ongoing clinical tolerance trials. The concept of "delayed tolerance" is presented, and ongoing preclinical studies in the nonhuman primate setting-including current limitations and hurdles regarding this approach-Are illustrated. In addition, a brief overview and update on cell-based tolerogenic clinical trials is provided. In a critical approach, advantages, limitations, and potential implications for the future of these different regimens are discussed.

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JO - Transplantation

JF - Transplantation

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Chimerism, transplant tolerance, and beyond

Abstract

ASJC Scopus subject areas

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