Chimerism, transplant tolerance, and beyond

Franka Messner, Joanna W. Etra, Jeffrey M. Dodd-O, Gerald Brandacher

Research output: Contribution to journalReview article

Abstract

The present review discusses current developments in tolerance induction for solid organ transplantation with a particular emphasis on chimerism-based approaches. It explains the basic mechanisms of chimerism-based tolerance and provides an update on ongoing clinical tolerance trials. The concept of "delayed tolerance" is presented, and ongoing preclinical studies in the nonhuman primate setting-including current limitations and hurdles regarding this approach-Are illustrated. In addition, a brief overview and update on cell-based tolerogenic clinical trials is provided. In a critical approach, advantages, limitations, and potential implications for the future of these different regimens are discussed.

Original languageEnglish (US)
Pages (from-to)1556-1567
Number of pages12
JournalTransplantation
Volume103
Issue number8
DOIs
StatePublished - Aug 1 2019

    Fingerprint

ASJC Scopus subject areas

  • Transplantation

Cite this