Abstract
The present review discusses current developments in tolerance induction for solid organ transplantation with a particular emphasis on chimerism-based approaches. It explains the basic mechanisms of chimerism-based tolerance and provides an update on ongoing clinical tolerance trials. The concept of "delayed tolerance" is presented, and ongoing preclinical studies in the nonhuman primate setting-including current limitations and hurdles regarding this approach-Are illustrated. In addition, a brief overview and update on cell-based tolerogenic clinical trials is provided. In a critical approach, advantages, limitations, and potential implications for the future of these different regimens are discussed.
Original language | English (US) |
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Pages (from-to) | 1556-1567 |
Number of pages | 12 |
Journal | Transplantation |
Volume | 103 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1 2019 |
ASJC Scopus subject areas
- Transplantation