Children with epilepsy and anxiety: Subcortical and cortical differences

Jana E. Jones, Daren C. Jackson, Karlee L. Chambers, Kevin Dabbs, David A. Hsu, Carl Stafstrom, Michael Seidenberg, Bruce P. Hermann

Research output: Contribution to journalArticle

Abstract

Objective Using a hypothesis-driven approach, subcortical and cortical regions implicated in anxiety disorders in the general population were examined in children with recent-onset epilepsy with versus without anxiety compared to controls. This study reports frequency of anxiety disorders while examining familial, clinical, and demographic variables associated with anxiety in children with epilepsy. Method Participants included 88 children with epilepsy aged 8-18 years: 25 with a current anxiety disorder and 63 children with epilepsy and no current anxiety disorder. Forty-nine controls without anxiety disorders were included. T1 volumetric magnetic resonance imaging (MRI) scans were collected; subcortical volumes and cortical thickness were computed using the FreeSurfer image analysis suite. Analyses focused on adjusted measures of subcortical volumes and cortical thickness. Results Relative to controls, larger left amygdala volumes were found in the Epilepsy with Anxiety group compared to the Epilepsy without Anxiety group (p = 0.027). In the hippocampus, there were no significant differences between groups. Examination of cortical thickness demonstrated that the Epilepsy with Anxiety group showed thinning in left medial orbitofrontal (p = 0.001), right lateral orbitofrontal (p = 0.017), and right frontal pole (p = 0.009). There were no differences between groups in age, sex, IQ, age of onset, medications, or duration of epilepsy. There were more family members with a history of anxiety disorders in the Epilepsy with Anxiety group compared to the Epilepsy without Anxiety group (p = 0.005). Significance Anxiety is a common psychiatric comorbidity in children with recent-onset epilepsy with volumetric enlargement of the amygdala and thinner cortex in orbital and other regions of prefrontal cortex, suggesting structural abnormalities in brain regions that are part of the dysfunctional networks reported in individuals with anxiety disorders in the general population. These findings are evident early in the course of epilepsy, are not related to chronicity of seizures, and may be linked to a family history of anxiety and depressive disorders.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalEpilepsia
Volume56
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Epilepsy
Anxiety
Anxiety Disorders
Amygdala
Prefrontal Cortex
Depressive Disorder
Age of Onset
Population
Psychiatry
Comorbidity
Hippocampus
Seizures
Age Groups
Magnetic Resonance Imaging
Demography
Brain

Keywords

  • Amygdala
  • Anxiety disorders
  • Pediatric Epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Jones, J. E., Jackson, D. C., Chambers, K. L., Dabbs, K., Hsu, D. A., Stafstrom, C., ... Hermann, B. P. (2015). Children with epilepsy and anxiety: Subcortical and cortical differences. Epilepsia, 56(2), 283-290. https://doi.org/10.1111/epi.12832

Children with epilepsy and anxiety : Subcortical and cortical differences. / Jones, Jana E.; Jackson, Daren C.; Chambers, Karlee L.; Dabbs, Kevin; Hsu, David A.; Stafstrom, Carl; Seidenberg, Michael; Hermann, Bruce P.

In: Epilepsia, Vol. 56, No. 2, 01.02.2015, p. 283-290.

Research output: Contribution to journalArticle

Jones, JE, Jackson, DC, Chambers, KL, Dabbs, K, Hsu, DA, Stafstrom, C, Seidenberg, M & Hermann, BP 2015, 'Children with epilepsy and anxiety: Subcortical and cortical differences', Epilepsia, vol. 56, no. 2, pp. 283-290. https://doi.org/10.1111/epi.12832
Jones JE, Jackson DC, Chambers KL, Dabbs K, Hsu DA, Stafstrom C et al. Children with epilepsy and anxiety: Subcortical and cortical differences. Epilepsia. 2015 Feb 1;56(2):283-290. https://doi.org/10.1111/epi.12832
Jones, Jana E. ; Jackson, Daren C. ; Chambers, Karlee L. ; Dabbs, Kevin ; Hsu, David A. ; Stafstrom, Carl ; Seidenberg, Michael ; Hermann, Bruce P. / Children with epilepsy and anxiety : Subcortical and cortical differences. In: Epilepsia. 2015 ; Vol. 56, No. 2. pp. 283-290.
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