Childhood Serum Anti-Fetal Brain Antibodies Do Not Predict Autism

Christina M. Morris, Andrew W. Zimmerman, Harvey Singer

Research output: Contribution to journalArticle

Abstract

Autoimmune hypotheses for autism include in utero transplacental exposure to maternal antibodies and acquired postnatal insults. Previous work demonstrated that some mothers of children with autistic disorder have specific antibodies against human fetal brain that differentiate them from mothers with typical children. In the present study, Western immunoblotting was used to determine whether children with autistic spectrum disorders (n = 29) have serum reactivity against human fetal brain that differs from that of controls (n = 14). There was no significant difference in reactivity, corrected for serum immunoglobulin G content and brain actin content and with special attention to reactive bands at 36, 39, 61, and 73 kDa, between autistic children and normal control subjects. Thus, in contrast to mothers, antibody reactivity against human fetal brain as measured in children ages 3-12 years does not appear to be a useful biomarker for autism.

Original languageEnglish (US)
Pages (from-to)288-290
Number of pages3
JournalPediatric Neurology
Volume41
Issue number4
DOIs
StatePublished - Oct 2009

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Autistic Disorder
Mothers
Antibodies
Brain
Serum
Maternal-Fetal Exchange
Actins
Immunoglobulin G
Biomarkers
Western Blotting

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

Cite this

Childhood Serum Anti-Fetal Brain Antibodies Do Not Predict Autism. / Morris, Christina M.; Zimmerman, Andrew W.; Singer, Harvey.

In: Pediatric Neurology, Vol. 41, No. 4, 10.2009, p. 288-290.

Research output: Contribution to journalArticle

Morris, Christina M. ; Zimmerman, Andrew W. ; Singer, Harvey. / Childhood Serum Anti-Fetal Brain Antibodies Do Not Predict Autism. In: Pediatric Neurology. 2009 ; Vol. 41, No. 4. pp. 288-290.
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