Childhood red cell aplasia

Blanche P. Alter

Research output: Contribution to journalArticlepeer-review

Abstract

Childhood red cell aplasia is defined as anemia, with reticulocytopenia, and usually bone marrow erythroid hypoplasia. The congenital disorder is called Diamond-Blackfan anemia. The acquired disease is short-lived, termed transient erythroblastopenia of childhood. The onset of Diamond-Blackfan anemia is usually prior to age 2 years. One-third have some physical abnormality. Erythroid progenitor cells are decreased in number and relatively insensitive to erythropoietin in tissue culture. Steroid treatment leads to clinical response in two-thirds. During steroid-induced or spontaneous remission, patients demonstrate fetal erythropoiesis. TEC occurs between ages 1 and 6 years. Physical examinations are normal. Spontaneous remissions occur rapidly. Erythrocytes are initially adult in character; fetal erythrocytes appear transiently during the recovery phase. Full recovery is expected.

Original languageEnglish (US)
Pages (from-to)121-139
Number of pages19
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume2
Issue number2
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

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