Childhood Obsessive–Compulsive Disorder: A Prospective Follow‐up Study

Martine F. Flament, Elisabeth Koby, Judith L. Rapoport, Carol J. Berg, Theodore Zahn, Christine Cox, Martha Denckla, Marge Lenane

Research output: Contribution to journalArticlepeer-review


Abstract Twenty‐five of 27 patients (93%) who had participated in a study of severe primary obsessive‐compulsive disorder with onset in childhood or adolescence, were seen 2–7 yrs after initial examination (mean, 4.4 yrs). They were compared to a group of normal controls matched for age, sex and IQ, and followed up for the same period. Continued psychopathology was striking for the patients, with only seven (28%), three males and four females, receiving no psychiatric diagnosis at follow‐up. Seventeen subjects (68%) still had obsessive‐compulsive disorder, 12 patients (48%) had another psychiatric disorder, most commonly anxiety and/or depression; neither initial response to clomipramine or any other baseline variable predicted outcome.

Original languageEnglish (US)
Pages (from-to)363-380
Number of pages18
JournalJournal of Child Psychology and Psychiatry
Issue number3
StatePublished - Mar 1990


  • Obsessive‐compulsive disorder
  • adolescence
  • clomipramine
  • follow‐up

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Psychiatry and Mental health


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