Childhood obesity: Genetic and environmental overlap with normal-range BMI

Claire M A Haworth, Robert Plomin, Susan Carnell, Jane Wardle

Research output: Contribution to journalArticle

Abstract

Objective: To understand the overlap between the etiology of obesity and normal variation in BMI in children. Methods and Procedures: Height and weight data were available from a large UK representative sample of twins: 2,342 same-sex pairs at 7 years and 3,526 same-sex pairs at 10 years. The twin method and model-fitting techniques were used to estimate genetic and environmental contributions to BMI. DeFries-Fulker (DF) extremes analysis was used to investigate genetic and environmental influences on the mean difference between obese and normal-weight children. Obesity was classified using the International Obesity Task Force (IOTF) criteria. Results: At both ages, BMI and obesity were highly heritable (0.60-0.74) and only modestly influenced by shared environmental factors (0.12-0.22). Extremes analyses indicated that genetic and environmental influences on obesity are quantitatively and qualitatively similar to those operating across the range of BMI. Discussion: Obesity is the extreme of the same genetic and environmental factors responsible for variation throughout the distribution of BMI. This finding implies that genes that influence obesity will also be associated with BMI in the normal range, and similar environmental influences will affect BMI in the clinical and normal range. Knowing that obesity is influenced by the same genetic and environmental factors that affect weight at all levels has implications for investigating the mechanisms for weight gain and developing interventions for weight control.

Original languageEnglish (US)
Pages (from-to)1585-1590
Number of pages6
JournalObesity
Volume16
Issue number7
DOIs
StatePublished - Jul 2008
Externally publishedYes

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Pediatric Obesity
Reference Values
Obesity
Weights and Measures
Advisory Committees
Weight Gain
Genes

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Childhood obesity : Genetic and environmental overlap with normal-range BMI. / Haworth, Claire M A; Plomin, Robert; Carnell, Susan; Wardle, Jane.

In: Obesity, Vol. 16, No. 7, 07.2008, p. 1585-1590.

Research output: Contribution to journalArticle

Haworth, Claire M A ; Plomin, Robert ; Carnell, Susan ; Wardle, Jane. / Childhood obesity : Genetic and environmental overlap with normal-range BMI. In: Obesity. 2008 ; Vol. 16, No. 7. pp. 1585-1590.
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