TY - JOUR
T1 - Childhood Factors Affecting Persistence and Desistence of Attention-Deficit/Hyperactivity Disorder Symptoms in Adulthood
T2 - Results From the MTA
AU - for the
AU - MTA Cooperative Group
AU - MTA Cooperative Group
AU - Roy, Arunima
AU - Hechtman, Lily
AU - Roy, Arunima
AU - Arnold, L. Eugene
AU - Sibley, Margaret H.
AU - Molina, Brooke S.G.
AU - Swanson, James M.
AU - Howard, Andrea L.
AU - Vitiello, Benedetto
AU - Severe, Joanne B.
AU - Jensen, Peter S.
AU - Arnold, L. Eugene
AU - Hoagwood, Kimberly
AU - Richters, John
AU - Vereen, Donald
AU - Hinshaw, Stephen P.
AU - Elliott, Glen R.
AU - Wells, Karen C.
AU - Epstein, Jeffery N.
AU - Murray, Desiree W.
AU - Conners, C. Keith
AU - March, John
AU - Swanson, James
AU - Wigal, Timothy
AU - Cantwell, Dennis P.
AU - Abikoff, Howard B.
AU - Hechtman, Lily
AU - Greenhill, Laurence L.
AU - Newcorn, Jeffrey H.
AU - Molina, Brooke
AU - Hoza, Betsy
AU - Pelham, William E.
AU - Gibbons, Robert D.
AU - Marcus, Sue
AU - Hur, Kwan
AU - Kraemer, Helena C.
AU - Hanley, Thomas
AU - Stern, Karen
N1 - Funding Information:
The work reported was supported by cooperative agreement grants and contracts from the National Institute of Mental Health (NIMH) and the National Institute on Drug Abuse (NIDA) to the following: University of California–Berkeley: U01 MH50461, N01MH12009, and HHSN271200800005-C; DA-8-5550; Duke University: U01 MH50477, N01MH12012, and HHSN271200800009-C; DA-8-5554; University of California– Irvine: U01MH50440, N01MH12011, and HHSN271200800006-C; DA-8-5551; Research Foundation for Mental Hygiene (New York State Psychiatric Institute/Columbia University): U01 MH50467, N01 MH12007, and HHSN271200800007-C; DA-8-5552; Long Island–Jewish Medical Center: U01 MH50453; New York University: N01MH 12004 and HHSN271200800004-C; DA-8-5549; University of Pittsburgh: U01 MH50467, N01 MH 12010, and HHSN271200800008-C; DA-8-5553; DA039881; and McGill University: N01MH12008 and HHSN271200800003-C; DA-8-5548. Dr. Roy was supported by the Ter Meulen grant of the Royal Netherlands Academy of Arts and Sciences (KNAW) to participate in this study. Drs. Roy and Hechtman had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. All authors have made substantial contributions to this study and qualify for authorship. Study concept and design: Drs. Roy, Hechtman, Arnold, and Howard. Acquisition, analysis, or interpretation of data: all authors. Manuscript drafting: Drs. Roy and Hechtman. Critical revision of the manuscript for important intellectual content: all authors. Final approval of version to be published: all authors. Obtained funding: Drs. Hechtman, Molina, and Swanson.
Publisher Copyright:
© 2016 American Academy of Child and Adolescent Psychiatry
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Objective To determine childhood factors that predict attention-deficit/hyperactivity disorder (ADHD) persistence and desistence in adulthood. Method Regression analyses were used to determine associations between childhood factors and adult ADHD symptom persistence in 453 participants (mean age, 25 years) from the Multimodal Treatment Study of Children with ADHD (MTA). Childhood IQ, total number of comorbidities, child-perceived parenting practices, child-perceived parent−child relationships, parental mental health problems, marital problems of parents, household income levels, and parental education were assessed at a mean age of 8 years in all participants. Adult ADHD persistence was defined using DSM-5 symptom counts either with or without impairment, as well as mean ADHD symptom scores on the Conners’ Adult ADHD Rating Scale (CAARS). Age, sex, MTA site, and childhood ADHD symptoms were covaried. Results The most important childhood predictors of adult ADHD symptom persistence were initial ADHD symptom severity (odds ratio [OR] = 1.89, standard error [SE] = 0.28, p =.025), comorbidities (OR = 1.19, SE = 0.07, p =.018), and parental mental health problems (OR = 1.30, SE = 0.09, p =.003). Childhood IQ, socioeconomic status, parental education, and parent−child relationships showed no associations with adult ADHD symptom persistence. Conclusion Initial ADHD symptom severity, parental mental health, and childhood comorbidity affect persistence of ADHD symptoms into adulthood. Addressing these areas early may assist in reducing adult ADHD persistence and functioning problems.
AB - Objective To determine childhood factors that predict attention-deficit/hyperactivity disorder (ADHD) persistence and desistence in adulthood. Method Regression analyses were used to determine associations between childhood factors and adult ADHD symptom persistence in 453 participants (mean age, 25 years) from the Multimodal Treatment Study of Children with ADHD (MTA). Childhood IQ, total number of comorbidities, child-perceived parenting practices, child-perceived parent−child relationships, parental mental health problems, marital problems of parents, household income levels, and parental education were assessed at a mean age of 8 years in all participants. Adult ADHD persistence was defined using DSM-5 symptom counts either with or without impairment, as well as mean ADHD symptom scores on the Conners’ Adult ADHD Rating Scale (CAARS). Age, sex, MTA site, and childhood ADHD symptoms were covaried. Results The most important childhood predictors of adult ADHD symptom persistence were initial ADHD symptom severity (odds ratio [OR] = 1.89, standard error [SE] = 0.28, p =.025), comorbidities (OR = 1.19, SE = 0.07, p =.018), and parental mental health problems (OR = 1.30, SE = 0.09, p =.003). Childhood IQ, socioeconomic status, parental education, and parent−child relationships showed no associations with adult ADHD symptom persistence. Conclusion Initial ADHD symptom severity, parental mental health, and childhood comorbidity affect persistence of ADHD symptoms into adulthood. Addressing these areas early may assist in reducing adult ADHD persistence and functioning problems.
KW - IQ
KW - adulthood
KW - attention-deficit/hyperactivity disorder (ADHD)
KW - comorbidity
KW - family
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U2 - 10.1016/j.jaac.2016.05.027
DO - 10.1016/j.jaac.2016.05.027
M3 - Article
AN - SCOPUS:85001085881
SN - 0890-8567
VL - 55
SP - 937-944.e4
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 11
ER -