Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response

B. D. Kirkpatrick, Francine Noel, Patricia D. Rouzier, Jan L. Powell, J. W. Pape, Grylande Bois, W. Kemper Alston, Catherine J. Larsson, Katherine Tenney, Cassandra Ventrone, Cheryl Powden, Meera Sreenivasan, Cynthia Louise Sears

Research output: Contribution to journalArticle

Abstract

Cryptosporidiosis in young children prompts local inflammation in the intestinal tract. We studied a cohort of young children with cryptosporidiosis to determine whether systemic inflammatory responses occur and, if so, to evaluate whether inflammation persists after infection. Cryptosporidiosis was associated with increased levels of interleukin-8 and tumor necrosis factor-α systemically, which persisted at 6 months after enrollment. The level of intestinal tumor necrosis factor-α was elevated at enrollment, but elevated levels did not persist. Worsening of malnutrition, particularly stunting, was observed after infection. The association of cryptosporidiosis, inflammation, and stunting in children with cryptosporidiosis warrants further evaluation.

Original languageEnglish (US)
Pages (from-to)604-608
Number of pages5
JournalClinical Infectious Diseases
Volume43
Issue number5
DOIs
StatePublished - Sep 1 2006

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Cryptosporidiosis
Growth Disorders
Inflammation
Tumor Necrosis Factor-alpha
Infection
Interleukin-8
Malnutrition

ASJC Scopus subject areas

  • Immunology

Cite this

Kirkpatrick, B. D., Noel, F., Rouzier, P. D., Powell, J. L., Pape, J. W., Bois, G., ... Sears, C. L. (2006). Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response. Clinical Infectious Diseases, 43(5), 604-608. https://doi.org/10.1086/506565

Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response. / Kirkpatrick, B. D.; Noel, Francine; Rouzier, Patricia D.; Powell, Jan L.; Pape, J. W.; Bois, Grylande; Alston, W. Kemper; Larsson, Catherine J.; Tenney, Katherine; Ventrone, Cassandra; Powden, Cheryl; Sreenivasan, Meera; Sears, Cynthia Louise.

In: Clinical Infectious Diseases, Vol. 43, No. 5, 01.09.2006, p. 604-608.

Research output: Contribution to journalArticle

Kirkpatrick, BD, Noel, F, Rouzier, PD, Powell, JL, Pape, JW, Bois, G, Alston, WK, Larsson, CJ, Tenney, K, Ventrone, C, Powden, C, Sreenivasan, M & Sears, CL 2006, 'Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response', Clinical Infectious Diseases, vol. 43, no. 5, pp. 604-608. https://doi.org/10.1086/506565
Kirkpatrick BD, Noel F, Rouzier PD, Powell JL, Pape JW, Bois G et al. Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response. Clinical Infectious Diseases. 2006 Sep 1;43(5):604-608. https://doi.org/10.1086/506565
Kirkpatrick, B. D. ; Noel, Francine ; Rouzier, Patricia D. ; Powell, Jan L. ; Pape, J. W. ; Bois, Grylande ; Alston, W. Kemper ; Larsson, Catherine J. ; Tenney, Katherine ; Ventrone, Cassandra ; Powden, Cheryl ; Sreenivasan, Meera ; Sears, Cynthia Louise. / Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response. In: Clinical Infectious Diseases. 2006 ; Vol. 43, No. 5. pp. 604-608.
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