Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response

B. D. Kirkpatrick, Francine Noel, Patricia D. Rouzier, Jan L. Powell, J. W. Pape, Grylande Bois, W. Kemper Alston, Catherine J. Larsson, Katherine Tenney, Cassandra Ventrone, Cheryl Powden, Meera Sreenivasan, Cynthia L. Sears

Research output: Contribution to journalArticlepeer-review

Abstract

Cryptosporidiosis in young children prompts local inflammation in the intestinal tract. We studied a cohort of young children with cryptosporidiosis to determine whether systemic inflammatory responses occur and, if so, to evaluate whether inflammation persists after infection. Cryptosporidiosis was associated with increased levels of interleukin-8 and tumor necrosis factor-α systemically, which persisted at 6 months after enrollment. The level of intestinal tumor necrosis factor-α was elevated at enrollment, but elevated levels did not persist. Worsening of malnutrition, particularly stunting, was observed after infection. The association of cryptosporidiosis, inflammation, and stunting in children with cryptosporidiosis warrants further evaluation.

Original languageEnglish (US)
Pages (from-to)604-608
Number of pages5
JournalClinical Infectious Diseases
Volume43
Issue number5
DOIs
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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