Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response

B. D. Kirkpatrick; Francine Noel; Patricia D. Rouzier; Jan L. Powell; J. W. Pape; Grylande Bois; W. Kemper Alston; Catherine J. Larsson; Katherine Tenney; Cassandra Ventrone; Cheryl Powden; Meera Sreenivasan; Cynthia L. Sears

doi:10.1086/506565

Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response

B. D. Kirkpatrick, Francine Noel, Patricia D. Rouzier, Jan L. Powell, J. W. Pape, Grylande Bois, W. Kemper Alston, Catherine J. Larsson, Katherine Tenney, Cassandra Ventrone, Cheryl Powden, Meera Sreenivasan, Cynthia L. Sears

School of Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Cryptosporidiosis in young children prompts local inflammation in the intestinal tract. We studied a cohort of young children with cryptosporidiosis to determine whether systemic inflammatory responses occur and, if so, to evaluate whether inflammation persists after infection. Cryptosporidiosis was associated with increased levels of interleukin-8 and tumor necrosis factor-α systemically, which persisted at 6 months after enrollment. The level of intestinal tumor necrosis factor-α was elevated at enrollment, but elevated levels did not persist. Worsening of malnutrition, particularly stunting, was observed after infection. The association of cryptosporidiosis, inflammation, and stunting in children with cryptosporidiosis warrants further evaluation.

Original language	English (US)
Pages (from-to)	604-608
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	43
Issue number	5
DOIs	https://doi.org/10.1086/506565
State	Published - Sep 1 2006

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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title = "Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response",

abstract = "Cryptosporidiosis in young children prompts local inflammation in the intestinal tract. We studied a cohort of young children with cryptosporidiosis to determine whether systemic inflammatory responses occur and, if so, to evaluate whether inflammation persists after infection. Cryptosporidiosis was associated with increased levels of interleukin-8 and tumor necrosis factor-α systemically, which persisted at 6 months after enrollment. The level of intestinal tumor necrosis factor-α was elevated at enrollment, but elevated levels did not persist. Worsening of malnutrition, particularly stunting, was observed after infection. The association of cryptosporidiosis, inflammation, and stunting in children with cryptosporidiosis warrants further evaluation.",

author = "Kirkpatrick, {B. D.} and Francine Noel and Rouzier, {Patricia D.} and Powell, {Jan L.} and Pape, {J. W.} and Grylande Bois and Alston, {W. Kemper} and Larsson, {Catherine J.} and Katherine Tenney and Cassandra Ventrone and Cheryl Powden and Meera Sreenivasan and Sears, {Cynthia L.}",

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AU - Noel, Francine

AU - Rouzier, Patricia D.

AU - Powell, Jan L.

AU - Pape, J. W.

AU - Bois, Grylande

AU - Alston, W. Kemper

AU - Larsson, Catherine J.

AU - Tenney, Katherine

AU - Ventrone, Cassandra

AU - Powden, Cheryl

AU - Sreenivasan, Meera

AU - Sears, Cynthia L.

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AB - Cryptosporidiosis in young children prompts local inflammation in the intestinal tract. We studied a cohort of young children with cryptosporidiosis to determine whether systemic inflammatory responses occur and, if so, to evaluate whether inflammation persists after infection. Cryptosporidiosis was associated with increased levels of interleukin-8 and tumor necrosis factor-α systemically, which persisted at 6 months after enrollment. The level of intestinal tumor necrosis factor-α was elevated at enrollment, but elevated levels did not persist. Worsening of malnutrition, particularly stunting, was observed after infection. The association of cryptosporidiosis, inflammation, and stunting in children with cryptosporidiosis warrants further evaluation.

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Childhood cryptosporidiosis is associated with a persistent systemic inflammatory response

Abstract

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