Childhood cognitive development after fetal growth restriction

E. Llurba, A. A. Baschat, O. M. Turan, J. Harding, L. M. McCowan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Objective To examine the relationship between prenatal umbilical artery (UA) and internal carotid artery (ICA) Doppler findings and cognitive development at 3 and 6 years in low-birth-weight children. Methods This was a study of 209 low-birth-weight (< 10th centile) children born after 28 gestational weeks with UA resistance index (RI) measured within 2 weeks before delivery. Children with normal UA- and ICA-RI were defined as small-for-gestational age (SGA) and those with abnormal UA or ICA Doppler findings as having fetal growth restriction (FGR). Cognitive ability at 3 and 6 years' corrected age was assessed using the fourth edition of the Stanford-Binet Intelligence Scale (SBIS) and compared between SGA and FGR groups. An SBIS score < 85 was considered to indicate delayed development. Results The median gestational age at diagnosis of abnormal fetal growth was 36.6 (range, 28-41) weeks. There were 87 (41.6%) children classified as having FGR and 122 (58.4%) as SGA. The mean global SBIS score at 3 years was 109.4 (SD, 22.8) and at 6 years it was 110.5 (SD, 13.9). Overall, 22 (10.5%) children had delayed development at 3 years. Total SBIS scores and individual domain scores did not differ between FGR and SGA groups at 3 or 6 years and similar proportions in each group had delayed development. Conclusion Abnormal prenatal UA and ICA Doppler findings are not associated with lower developmental scores in low-birth-weight children delivered in the third trimester of pregnancy.

Original languageEnglish (US)
Pages (from-to)383-389
Number of pages7
JournalUltrasound in Obstetrics and Gynecology
Issue number4
StatePublished - Apr 2013
Externally publishedYes


  • Doppler
  • birth weight
  • child development
  • developmental disabilities
  • fetal growth restriction
  • infant
  • newborn
  • small-for-gestational age
  • ultrasonography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynecology


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