Childhood Adrenoleukodystrophy: Failure of Intensive Immunosuppression to Arrest Neurologic Progression

Sakkubai Naidu; Hugo W. Moser; Susan O'toole; Michael J. Bresnan; Diane Griffin

doi:10.1001/archneur.1988.00520320032011

Childhood Adrenoleukodystrophy: Failure of Intensive Immunosuppression to Arrest Neurologic Progression

Sakkubai Naidu, Hugo W. Moser, Susan O'toole, Michael J. Bresnan, Diane Griffin

School of Medicine

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Cyclophosphamide in a dosage of 350 to 700 mg/m2/d was administered for five to 11 days to four patients with childhood adrenoleukodystrophy (ALD) and to one patient with the adult cerebral form of the disease. The rate of neurologic progression in the four patients with childhood ALD did not differ from that of 167 untreated patients with childhood ALD surveyed previously.

Original language	English (US)
Pages (from-to)	846-848
Number of pages	3
Journal	Archives of neurology
Volume	45
Issue number	8
DOIs	https://doi.org/10.1001/archneur.1988.00520320032011
State	Published - Aug 1988

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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title = "Childhood Adrenoleukodystrophy: Failure of Intensive Immunosuppression to Arrest Neurologic Progression",

abstract = "Cyclophosphamide in a dosage of 350 to 700 mg/m2/d was administered for five to 11 days to four patients with childhood adrenoleukodystrophy (ALD) and to one patient with the adult cerebral form of the disease. The rate of neurologic progression in the four patients with childhood ALD did not differ from that of 167 untreated patients with childhood ALD surveyed previously.",

author = "Sakkubai Naidu and Moser, {Hugo W.} and Susan O'toole and Bresnan, {Michael J.} and Diane Griffin",

note = "Funding Information: Thisinvestigationwassupportedinpartby Public Health Service grant HD 10981 from the NationalInstitutesofHealth,Bethesda,Md.",

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AU - Moser, Hugo W.

AU - O'toole, Susan

AU - Bresnan, Michael J.

AU - Griffin, Diane

N1 - Funding Information: Thisinvestigationwassupportedinpartby Public Health Service grant HD 10981 from the NationalInstitutesofHealth,Bethesda,Md.

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AB - Cyclophosphamide in a dosage of 350 to 700 mg/m2/d was administered for five to 11 days to four patients with childhood adrenoleukodystrophy (ALD) and to one patient with the adult cerebral form of the disease. The rate of neurologic progression in the four patients with childhood ALD did not differ from that of 167 untreated patients with childhood ALD surveyed previously.

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Childhood Adrenoleukodystrophy: Failure of Intensive Immunosuppression to Arrest Neurologic Progression

Abstract

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