Chest CT texture analysis for response assessment in systemic sclerosis

C. Kloth, J. Henes, T. Xenitidis, W. M. Thaiss, A. C. Blum, J. Fritz, K. Nikolaou, M. Horger, Sorin Dumitru Ioanoviciu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Purpose: To evaluate the role of CT-textural features for monitoring lung involvement in subjects with systemic sclerosis(SSc) undergoing autologous stem cell transplantation(SCT) by comparison with semi-quantitative chest-CT, pulmonary function tests(PFT) and clinical parameters (modified Rodnan skin score[mRSS]). Methods: In a retrospective single centre analysis, we identified 23 consecutive subjects(11male) with SSc between 07/2005 and 11/2016 that underwent chest CTs before, 6 and 12 months post-SCT. Response to therapy was defined at 6 months after transplantation as stabilisation or improvement in FVC > 10% and DLCOSB > 10%. CT-texture analysis(CTTA) including mean, entropy and uniformity were calculated. Results: PFT classified the subjects into responders(18/23;78%) and non-responders(5/23;22%). mRSS improved in responders from 28.46 ± 9.53 to 15.70 ± 10.07 6 months after auto-SCT(p =.001) whereas in non-responders no significant improvement was registered. Fibrosis score increased significantly(mean2.33 ± 1.23 vs.1.41 ± 0.78; p =.005) in non-responders after 6 and 12months. Significant lower mean intensity and entropy of skewness and higher uniformity of skewness was found in responders vs. non-responders at baseline. Significant changes in CTTA-parameters were found in both responders and non-responders at 6months and only in responders also at 12months post-SCT. Conclusions: Changes in CT-textural features after SCT are associated with visual CT evaluation of SSc-related lung abnormalities, but complementary provide information about therapy-induced, structural pulmonary changes.

Original languageEnglish (US)
Pages (from-to)50-58
Number of pages9
JournalEuropean Journal of Radiology
StatePublished - Apr 2018


  • Autologous transplantation
  • Fibrosis
  • Lung
  • Stem cell transplantation
  • Systemic sclerosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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