Chemotherapy of disseminated malignant melanoma with dimethyl triazeno imidazole carboxamide and dactinomycin

R. E. Gerner; G. E. Moore; M. S. Didolkar

doi:10.1002/1097-0142(197310)32:4<756::AID-CNCR2820320404>3.0.CO;2-6

Chemotherapy of disseminated malignant melanoma with dimethyl triazeno imidazole carboxamide and dactinomycin

R. E. Gerner, G. E. Moore, M. S. Didolkar

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Seventy‐one patients with disseminated malignant melanoma were treated with combination chemotherapy consisting of dimethyl triazeno imidazole carboxamide (DTIC) and dactinomycin. An objective response rate of 20% was observed in 69 evaluable patients. The addition of dactinomycin with DTIC did not provide enhanced therapeutic benefit over that of DTIC as a single agent when compared to previous studies. There was increased toxicity. Problems of hemorrhage in metastatic cerebral lesions were encountered.

Original language	English (US)
Pages (from-to)	756-760
Number of pages	5
Journal	Cancer
Volume	32
Issue number	4
DOIs	https://doi.org/10.1002/1097-0142(197310)32:4<756::AID-CNCR2820320404>3.0.CO;2-6
State	Published - Oct 1973
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(197310)32:4<756::AID-CNCR2820320404>3.0.CO;2-6

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title = "Chemotherapy of disseminated malignant melanoma with dimethyl triazeno imidazole carboxamide and dactinomycin",

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author = "Gerner, {R. E.} and Moore, {G. E.} and Didolkar, {M. S.}",

year = "1973",

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AU - Gerner, R. E.

AU - Moore, G. E.

AU - Didolkar, M. S.

PY - 1973/10

Y1 - 1973/10

N2 - Seventy‐one patients with disseminated malignant melanoma were treated with combination chemotherapy consisting of dimethyl triazeno imidazole carboxamide (DTIC) and dactinomycin. An objective response rate of 20% was observed in 69 evaluable patients. The addition of dactinomycin with DTIC did not provide enhanced therapeutic benefit over that of DTIC as a single agent when compared to previous studies. There was increased toxicity. Problems of hemorrhage in metastatic cerebral lesions were encountered.

AB - Seventy‐one patients with disseminated malignant melanoma were treated with combination chemotherapy consisting of dimethyl triazeno imidazole carboxamide (DTIC) and dactinomycin. An objective response rate of 20% was observed in 69 evaluable patients. The addition of dactinomycin with DTIC did not provide enhanced therapeutic benefit over that of DTIC as a single agent when compared to previous studies. There was increased toxicity. Problems of hemorrhage in metastatic cerebral lesions were encountered.

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Chemotherapy of disseminated malignant melanoma with dimethyl triazeno imidazole carboxamide and dactinomycin

Abstract

ASJC Scopus subject areas

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