Chemotherapy in the treatment of locally advanced head and neck cancer

Research output: Contribution to journalArticle

Abstract

Three decades of collaborative research have led to the integration of platinum-based chemotherapy into the curative management of squamous cell carcinoma of the head and neck and gains in local-regional control, organ preservation and survival endpoints. Concomitant cisplatin-based chemotherapy and radiotherapy is the strategy that has proven most effective for organ preservation for larynx and oropharynx cancers, the treatment of unresectable disease, nasopharyngeal cancer and the post-operative adjuvant treatment of patients at high risk of recurrence. The evolution of current indications for this multimodality approach is reviewed and current areas of investigation discussed. Nearly all patients with locally advanced head and neck cancer receive chemotherapy as part of initial curative treatment. The focus of future trials should be on survival improvement, toxicity reduction and risk stratification for treatment decision making.

Original languageEnglish (US)
Pages (from-to)701-707
Number of pages7
JournalJournal of Surgical Oncology
Volume97
Issue number8
DOIs
StatePublished - Jun 15 2008

Fingerprint

Head and Neck Neoplasms
Organ Preservation
Drug Therapy
Nasopharyngeal Neoplasms
Oropharyngeal Neoplasms
Tissue Survival
Laryngeal Neoplasms
Risk Reduction Behavior
Therapeutics
Platinum
Cisplatin
Decision Making
Radiotherapy
Recurrence
Survival
Research

Keywords

  • Chemoradiation
  • Chemotherapy
  • Head and neck cancer

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Chemotherapy in the treatment of locally advanced head and neck cancer. / Forastiere, Arlene A.

In: Journal of Surgical Oncology, Vol. 97, No. 8, 15.06.2008, p. 701-707.

Research output: Contribution to journalArticle

@article{c2ae18f0f90949ebbe2f411948e3df16,
title = "Chemotherapy in the treatment of locally advanced head and neck cancer",
abstract = "Three decades of collaborative research have led to the integration of platinum-based chemotherapy into the curative management of squamous cell carcinoma of the head and neck and gains in local-regional control, organ preservation and survival endpoints. Concomitant cisplatin-based chemotherapy and radiotherapy is the strategy that has proven most effective for organ preservation for larynx and oropharynx cancers, the treatment of unresectable disease, nasopharyngeal cancer and the post-operative adjuvant treatment of patients at high risk of recurrence. The evolution of current indications for this multimodality approach is reviewed and current areas of investigation discussed. Nearly all patients with locally advanced head and neck cancer receive chemotherapy as part of initial curative treatment. The focus of future trials should be on survival improvement, toxicity reduction and risk stratification for treatment decision making.",
keywords = "Chemoradiation, Chemotherapy, Head and neck cancer",
author = "Forastiere, {Arlene A.}",
year = "2008",
month = "6",
day = "15",
doi = "10.1002/jso.21012",
language = "English (US)",
volume = "97",
pages = "701--707",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "8",

}

TY - JOUR

T1 - Chemotherapy in the treatment of locally advanced head and neck cancer

AU - Forastiere, Arlene A.

PY - 2008/6/15

Y1 - 2008/6/15

N2 - Three decades of collaborative research have led to the integration of platinum-based chemotherapy into the curative management of squamous cell carcinoma of the head and neck and gains in local-regional control, organ preservation and survival endpoints. Concomitant cisplatin-based chemotherapy and radiotherapy is the strategy that has proven most effective for organ preservation for larynx and oropharynx cancers, the treatment of unresectable disease, nasopharyngeal cancer and the post-operative adjuvant treatment of patients at high risk of recurrence. The evolution of current indications for this multimodality approach is reviewed and current areas of investigation discussed. Nearly all patients with locally advanced head and neck cancer receive chemotherapy as part of initial curative treatment. The focus of future trials should be on survival improvement, toxicity reduction and risk stratification for treatment decision making.

AB - Three decades of collaborative research have led to the integration of platinum-based chemotherapy into the curative management of squamous cell carcinoma of the head and neck and gains in local-regional control, organ preservation and survival endpoints. Concomitant cisplatin-based chemotherapy and radiotherapy is the strategy that has proven most effective for organ preservation for larynx and oropharynx cancers, the treatment of unresectable disease, nasopharyngeal cancer and the post-operative adjuvant treatment of patients at high risk of recurrence. The evolution of current indications for this multimodality approach is reviewed and current areas of investigation discussed. Nearly all patients with locally advanced head and neck cancer receive chemotherapy as part of initial curative treatment. The focus of future trials should be on survival improvement, toxicity reduction and risk stratification for treatment decision making.

KW - Chemoradiation

KW - Chemotherapy

KW - Head and neck cancer

UR - http://www.scopus.com/inward/record.url?scp=44949232259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44949232259&partnerID=8YFLogxK

U2 - 10.1002/jso.21012

DO - 10.1002/jso.21012

M3 - Article

C2 - 18493921

AN - SCOPUS:44949232259

VL - 97

SP - 701

EP - 707

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 8

ER -