Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions

E. J. Fuchs, A. Seher, V. Altomonte, H. G. Braine, R. L. Humphrey, R. J. Jones, S. J. Noga, K. Schepers, S. K. Wright, G. B. Vogelsang

Research output: Contribution to journalArticlepeer-review

Abstract

Two patients with multiple myeloma in relapse after allogeneic BMT received donor lymphocyte infusions (DLI) but later required chemotherapy for treatment of myeloma-related complications. In both patients, recovery from chemotherapy-induced aplasia was accompanied by manifestations of graft-versus-host reactions. The first patient developed grade II acute GVHD and a complete remission which has lasted > 22 months. The second patient developed grade III acute GVHD but died with co-existing GVHD and extensive extramedullary myeloma. These results demonstrate that chemotherapy does not nullify the ability of donor lymphocytes to mediate graft-versus-host reactions.

Original languageEnglish (US)
Pages (from-to)303-305
Number of pages3
JournalBone marrow transplantation
Volume22
Issue number3
DOIs
StatePublished - 1998

Keywords

  • Bone marrow transplantation
  • Chemotherapy
  • Graft-versus-host disease
  • Graft-versus-myeloma
  • Leukocyte transfusions
  • Multiple myeloma

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint Dive into the research topics of 'Chemotherapy does not nullify the ability of donor lymphocyte infusions to mediate graft-versus-host reactions'. Together they form a unique fingerprint.

Cite this