Chemotherapy-associated hepatotoxicity

Do we need to be concerned?

Michael A. Choti

Research output: Contribution to journalArticle

Abstract

Curative resection of liver metastases from colorectal cancer is associated with improved overall survival rates, making complete resection the goal of therapy for many patients. The addition of newer, more active chemotherapeutic regimens has prolonged patient survival in those with advanced disease and increased the number of patients eligible for surgical therapy. However, concerns regarding chemotherapy-associated liver injury may have a negative impact on the ability to offer potentially curative therapy and may increase morbidity in some patients. Specific forms of liver injury have been associated with various chemotherapeutic regimens, including steatosis and steatohepatitis with prolonged fluorouracil and irinotecan therapy, and sinusoidal injury with oxaliplatin-based regimens. While the histologic association appears likely, the contribution of chemotherapy-associated hepatotoxicity to postoperative morbidity remains ill defined.

Original languageEnglish (US)
Pages (from-to)2391-2394
Number of pages4
JournalAnnals of Surgical Oncology
Volume16
Issue number9
DOIs
StatePublished - Sep 2009

Fingerprint

Drug Therapy
irinotecan
oxaliplatin
Liver
Wounds and Injuries
Morbidity
Fatty Liver
Therapeutics
Fluorouracil
Colorectal Neoplasms
Survival Rate
Neoplasm Metastasis
Survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Chemotherapy-associated hepatotoxicity : Do we need to be concerned? / Choti, Michael A.

In: Annals of Surgical Oncology, Vol. 16, No. 9, 09.2009, p. 2391-2394.

Research output: Contribution to journalArticle

Choti, Michael A. / Chemotherapy-associated hepatotoxicity : Do we need to be concerned?. In: Annals of Surgical Oncology. 2009 ; Vol. 16, No. 9. pp. 2391-2394.
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