Chemotaxis: Signalling the way forward

Peter J.M. Van Haastert, Peter N. Devreotes

Research output: Contribution to journalReview articlepeer-review

Abstract

During random locomotion, human neutrophils and Dictyostelium discoideum amoebae repeatedly extend and retract cytoplasmic processes. During directed cell migration - chemotaxis - these pseudopodia form predominantly at the leading edge in response to the local accumulation of certain signalling molecules. Concurrent changes in actin and myosin enable the cell to move towards the stimulus. Recent studies are beginning to identify an intricate network of signalling molecules that mediate these processes, and how these molecules become localized in the cell is now becoming clear.

Original languageEnglish (US)
Pages (from-to)626-634
Number of pages9
JournalNature Reviews Molecular Cell Biology
Volume5
Issue number8
DOIs
StatePublished - Aug 2004

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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