Chemotaxis of rat brain astrocytes to platelet derived growth factor

J. P. Bressler, G. R. Grotendorst, C. Levitov, L. M. Hjelmeland

Research output: Contribution to journalArticlepeer-review

Abstract

Using a purified population of rat brain astrocytes prepared from neonatal cortex, we investigated the chemotaxis of astroglia to several well characterized growth factors. Chemotactic activity for astrocytes was found for the platelet derived growth factor with a half maximal response occurring at 0.5 ng/ml as compared with a value of 2-3 ng/ml obtained for NIH/3T3 fibroblasts in control experiments. Other growth factors including epidermal growth factor, fibroblast growth factor and insulin were inactive as chemoattractants. Affinity purified fibronectin was also found to stimulate the migration of astroglia, with half maximal doses of approximately 1 μg/ml relative to maximal responses to platelet derived growth factor.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalBrain research
Volume344
Issue number2
DOIs
StatePublished - Oct 7 1985
Externally publishedYes

Keywords

  • astrocyte
  • chemotaxis
  • fibronectin
  • platelet derived growth factor
  • wound repair

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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