Chemosensitivity testing with ChemoFx and overall survival in primary ovarian cancer

Thomas J. Herzog, Thomas C. Krivak, Amanda Nickles Fader, Robert L. Coleman

Research output: Contribution to journalArticle

Abstract

Objective: We sought to determine the association between tumor responses in vitro to platinum therapy by using the ChemoFx drug response marker and overall survival (OS) after first-line platinum-based chemotherapy in patients with advanced-stage primary ovarian cancer (POC). Study Design: Chemosensitivity testing was performed in vitro on tumors from 192 POC patients. Tumors were classified as responsive, intermediately responsive, and nonresponsive to chemotherapy. Physicians made all management decisions. Survival status was retrieved from the Social Security Death Index. OS was modeled using Cox proportional hazard regression analysis. Results: Median OS was 72.5 months for patients with tumors categorized as responsive, 48.6 months for intermediately responsive, and 28.2 months for nonresponsive (P = .03; hazard ratio, 0.70; 95% confidence interval, 0.50-0.97). The ChemoFx prediction of responses to platinum agents was an independent predictor of OS. Conclusion: Results of chemosensitivity testing with a drug response marker for therapy was predictive of OS in POC patients.

Original languageEnglish (US)
Pages (from-to)68.e1-68.e6
JournalAmerican journal of obstetrics and gynecology
Volume203
Issue number1
DOIs
StatePublished - Jul 2010

Keywords

  • chemotherapy drug response marker
  • in vitro chemosensitivity testing
  • ovarian cancer
  • platinum-based chemotherapy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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