Chemoselective attachment of small molecule effector functionality to human adenoviruses facilitates gene delivery to cancer cells

Partha Sarathi Banerjee, Philomena Ostapchuk, Patrick Hearing, Isaac Carrico

Research output: Contribution to journalArticle

Abstract

We demonstrate here a novel two-step "click" labeling process in which adenoviral particles are first metabolically labeled during production with unnatural azido sugars. Subsequent chemoselective modification allows access to viruses decorated with a broad array of effector functionality. Adenoviruses modified with folate, a known cancer-targeting motif, demonstrated a marked increase in gene delivery to a murine cancer cell line.

Original languageEnglish (US)
Pages (from-to)13615-13617
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number39
DOIs
StatePublished - Oct 6 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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