Chemoreceptors in Caulobacter crescentus: Trimers of receptor dimers in a partially ordered hexagonally packed array

Cezar M. Khursigara, Xiongwu Wu, Sriram Subramaniam

Research output: Contribution to journalArticle

Abstract

Chemoreceptor arrays are macromolecular complexes that form extended assemblies primarily at the poles of bacterial cells and mediate chemotaxis signal transduction, ultimately controlling cellular motility. We have used cryo-electron tomography to determine the spatial distribution and molecular architecture of signaling molecules that comprise chemoreceptor arrays in wild-type Caulobacter crescentus cells. We demonstrate that chemoreceptors are organized as trimers of receptor dimers, forming partially ordered hexagonally packed arrays of signaling complexes in the cytoplasmic membrane. This novel organization at the threshold between order and disorder suggests how chemoreceptors and associated molecules are arranged in signaling assemblies to respond dynamically in the activation and adaptation steps of bacterial chemotaxis.

Original languageEnglish (US)
Pages (from-to)6805-6810
Number of pages6
JournalJournal of Bacteriology
Volume190
Issue number20
DOIs
StatePublished - Oct 2008
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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