Chemoprotective potential of phase 2 enzyme inducers

Ryan A. Dick; Thomas W. Kensler

doi:10.1586/14737140.2.5.581

Chemoprotective potential of phase 2 enzyme inducers

Ryan A. Dick, Thomas W. Kensler

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

In this review we summarize recent data on the use of phase 2 enzyme inducers as cancer chemopreventive agents in preclinical and clinical studies. These agents elevate the expression of genes involved in the detoxication of electrophiles and free radicals that contribute to carcinogenesis. Their mechanisms of action, efficacy and limitations are discussed. Particular attention is paid to isothiocyante and dithiolothione classes of agents, as these are the most developed.

Original language	English (US)
Pages (from-to)	581-592
Number of pages	12
Journal	Expert Review of Anticancer Therapy
Volume	2
Issue number	5
DOIs	https://doi.org/10.1586/14737140.2.5.581
State	Published - Oct 2002

Keywords

Chemoprotective
Phase 2 enzyme

ASJC Scopus subject areas

Oncology
Pharmacology (medical)

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10.1586/14737140.2.5.581

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abstract = "In this review we summarize recent data on the use of phase 2 enzyme inducers as cancer chemopreventive agents in preclinical and clinical studies. These agents elevate the expression of genes involved in the detoxication of electrophiles and free radicals that contribute to carcinogenesis. Their mechanisms of action, efficacy and limitations are discussed. Particular attention is paid to isothiocyante and dithiolothione classes of agents, as these are the most developed.",

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AB - In this review we summarize recent data on the use of phase 2 enzyme inducers as cancer chemopreventive agents in preclinical and clinical studies. These agents elevate the expression of genes involved in the detoxication of electrophiles and free radicals that contribute to carcinogenesis. Their mechanisms of action, efficacy and limitations are discussed. Particular attention is paid to isothiocyante and dithiolothione classes of agents, as these are the most developed.

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Chemoprotective potential of phase 2 enzyme inducers

Abstract

Keywords

ASJC Scopus subject areas

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