Chemoprotective potential of phase 2 enzyme inducers

Ryan A. Dick, Thomas W. Kensler

Research output: Contribution to journalReview articlepeer-review

Abstract

In this review we summarize recent data on the use of phase 2 enzyme inducers as cancer chemopreventive agents in preclinical and clinical studies. These agents elevate the expression of genes involved in the detoxication of electrophiles and free radicals that contribute to carcinogenesis. Their mechanisms of action, efficacy and limitations are discussed. Particular attention is paid to isothiocyante and dithiolothione classes of agents, as these are the most developed.

Original languageEnglish (US)
Pages (from-to)581-592
Number of pages12
JournalExpert Review of Anticancer Therapy
Volume2
Issue number5
DOIs
StatePublished - Oct 2002

Keywords

  • Chemoprotective
  • Phase 2 enzyme

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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