Chemoprotection against cancer by isothiocyanates: A focus on the animal models and the protective mechanisms

Albena T. Dinkova-Kostova

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The isothiocyanates are among the most extensively studied chemoprotective agents. They are derived from glucosinolate precursors by the action of β-thioglucosidase enzymes (myrosinases). The Cruciferae family represents a rich source of glucosinolates. Notably, nearly all of the biological activities of glucosinolates, in both plants and animals, are attributable to their cognate hydrolytic products, and the isothiocyanates are prominent examples. In contrast to their relatively inert glucosinolate precursors, the isothiocyanates are endowed with high chemical reactivity, especially with sulfur-centered nucleophiles, such as protein cysteine residues. There are numerous examples of the chemoprotective effects of isothiocyanates in a number of animal models of experimental carcinogenesis at various organ sites and against carcinogens of several different types. It is becoming increasingly clear that this efficient protection is due to multiple mechanisms, including induction of cytoprotective proteins through the Keap1/Nrf2/ARE pathway, inhibition of proinflammatory responses through the NFκB pathway, induction of cell cycle arrest and apoptosis, effects on heat shock proteins, and inhibition of angiogenesis and metastasis. Because the isothiocyanates affect the function of transcription factors and ultimately the expression of networks of genes, such protection is comprehensive and long-lasting.

Original languageEnglish (US)
Title of host publicationTopics in Current Chemistry
Pages179-202
Number of pages24
Volume329
DOIs
StatePublished - 2013

Publication series

NameTopics in Current Chemistry
Volume329
ISSN (Print)03401022

Keywords

  • Glucosinolate
  • Keap1
  • NFκB
  • NQO1
  • Nrf2
  • Phenethyl isothiocyanate
  • Sulforaphane

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Dinkova-Kostova, A. T. (2013). Chemoprotection against cancer by isothiocyanates: A focus on the animal models and the protective mechanisms. In Topics in Current Chemistry (Vol. 329, pp. 179-202). (Topics in Current Chemistry; Vol. 329). https://doi.org/10.1007/128-2012-337