Chemokines, receptors, and their role in cardiovascular pathology

J. M. Wang, S. Su, W. Gong, J. J. Oppenheim

Research output: Contribution to journalReview article

Abstract

A superfamily of leukocyte chemotactic proteins, known as chemokines, has been identified during the past decade. Chemokines selectively attract and activate different leukocyte subpopulations and are key mediators of a variety of patho-physiological states, including hematopoiesis, inflammation, infection, allergy, atheroslerosis, reperfusion injury, as well as malignant tumors. Chemokines bind and activate a number of specific or promiscuous, G-protein-coupled seven-transmembrane receptors. Some of these receptors are utilized by human immunodeficiency virus type 1 as essential fusion co-factors. Further understanding of the role of chemokines and their receptors in host defense will help develop means by which the beneficial versus detrimental effects of these molecules can be balanced.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalInternational Journal of Clinical and Laboratory Research
Volume28
Issue number2
DOIs
StatePublished - Jun 1 1998
Externally publishedYes

Keywords

  • Atherosclerosis
  • Chemokines
  • Receptors
  • Reperfusion

ASJC Scopus subject areas

  • Clinical Biochemistry

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