Abstract
A superfamily of leukocyte chemotactic proteins, known as chemokines, has been identified during the past decade. Chemokines selectively attract and activate different leukocyte subpopulations and are key mediators of a variety of patho-physiological states, including hematopoiesis, inflammation, infection, allergy, atheroslerosis, reperfusion injury, as well as malignant tumors. Chemokines bind and activate a number of specific or promiscuous, G-protein-coupled seven-transmembrane receptors. Some of these receptors are utilized by human immunodeficiency virus type 1 as essential fusion co-factors. Further understanding of the role of chemokines and their receptors in host defense will help develop means by which the beneficial versus detrimental effects of these molecules can be balanced.
Original language | English (US) |
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Pages (from-to) | 83-90 |
Number of pages | 8 |
Journal | International Journal of Clinical and Laboratory Research |
Volume | 28 |
Issue number | 2 |
DOIs | |
State | Published - Jun 1998 |
Externally published | Yes |
Keywords
- Atherosclerosis
- Chemokines
- Receptors
- Reperfusion
ASJC Scopus subject areas
- Clinical Biochemistry