Chemokines in chronic progressive neurological diseases: HTLV-1 associated myelopathy and multiple sclerosis

P. A. Calabresi, R. Martin, S. Jacobson

Research output: Contribution to journalArticlepeer-review

Abstract

It is hypothesized that in MS and HTLV-1, chemokine and chemokine receptor expression are important mechanisms by which T cells migrate to sites of inflammation. Preliminary evidence supports the roles of several chemokines, including MIP 1β, in mediating the enhanced migration capacity of MS derived PBLs. In addition, the ligand CCR-5 seems to be up regulated on PBLs from some MS patients. Analysis of T cell clones does not reveal a definite correlation between cytokine phenotype and chemokine receptor profile. The chemokines and chemokine receptor family are likely to be important molecules in chronic progressive neurological diseases, in which immune cells invade the central nervous system.

Original languageEnglish (US)
Pages (from-to)102-108
Number of pages7
JournalJournal of neurovirology
Volume5
Issue number1
DOIs
StatePublished - Jan 1 1999
Externally publishedYes

Keywords

  • Chemokine receptors
  • HTLV-1
  • Migration
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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