TY - JOUR
T1 - Chemokines and their role in tumor growth and metastasis
AU - Wang, Ji Ming
AU - Deng, Xiyun
AU - Gong, Wanghua
AU - Su, Shaobo
N1 - Funding Information:
The authors thank Drs. J.J. Oppenheim, O.M.Z. Howard and O. Chertov for reviewing the article; Ms. K. Bengali, and Ms. N. Dunlop for technical assistance. S. Su is supported in part by a fellowship from the Office of the International Affairs, NCI, NIH.
PY - 1998/11/1
Y1 - 1998/11/1
N2 - Chemokines are a superfamily of pro-inflammatory polypeptide cytokines that selectively attract and activate different cell types. Many patho- physiological conditions require the participation of chemokines, including inflammation, infection, tissue injury, allergy, cardiovascular diseases, as well as malignant tumors. Chemokines activate cells through their binding to shared or unique cell surface receptors which belong to the seven- transmembrane, G-protein-coupled Rhodopsin superfamily. The role of chemokines in malignant tumors is complex: while some chemokines may enhance innate or specific host immunity against tumor implantation, others may favor tumor growth and metastasis by promoting tumor cell proliferation, migration or neovascularization in tumor tissue. In this review, the authors summarize some of the recent advances in chemokine research and emphasis is made on the effect of chemokines in tumor growth and metastasis.
AB - Chemokines are a superfamily of pro-inflammatory polypeptide cytokines that selectively attract and activate different cell types. Many patho- physiological conditions require the participation of chemokines, including inflammation, infection, tissue injury, allergy, cardiovascular diseases, as well as malignant tumors. Chemokines activate cells through their binding to shared or unique cell surface receptors which belong to the seven- transmembrane, G-protein-coupled Rhodopsin superfamily. The role of chemokines in malignant tumors is complex: while some chemokines may enhance innate or specific host immunity against tumor implantation, others may favor tumor growth and metastasis by promoting tumor cell proliferation, migration or neovascularization in tumor tissue. In this review, the authors summarize some of the recent advances in chemokine research and emphasis is made on the effect of chemokines in tumor growth and metastasis.
KW - Chemokines
KW - Growth and metastasis of tumors
KW - Leukocyte
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U2 - 10.1016/S0022-1759(98)00128-8
DO - 10.1016/S0022-1759(98)00128-8
M3 - Article
C2 - 9839921
AN - SCOPUS:0001825042
SN - 0022-1759
VL - 220
SP - 1
EP - 17
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
IS - 1-2
ER -