Chemokines and allergic disease

Renate Nickel, Lisa A. Beck, Cristiana Stellato, Robert P. Schleimer

Research output: Contribution to journalArticle

Abstract

Understanding the chemokine network has become one of the great challenges for researchers interested in inflammatory mechanisms and inflammation-based diseases. The complexity and diversity of the system provide not only a daunting task for its comprehension but also numerous opportunities for development of new, targeted therapies. It is now certain that chemokines are involved as important mediators of allergic inflammation; the fine details and scope of their roles are now under investigation. Presumably, because of distinct pressures on the immune systems of people living in different geographic regions, genetic variation of ligands, receptors, and regulatory regions in the network have emerged. Establishing the roles of these polymorphisms in determining disease susceptibility or progression among individuals and in distinct ethnic groups will provide a basis for improved understanding and treatment of allergic diseases.

Original languageEnglish (US)
Pages (from-to)723-742
Number of pages20
JournalThe Journal of Allergy and Clinical Immunology
Volume104
Issue number4 I
StatePublished - 1999

Keywords

  • Allergic disease
  • Angiogenesis
  • Chemokine
  • Chemotaxis
  • Cytokines
  • Eosinophil
  • Glucocorticoid s
  • Hematopoieses
  • Mediators
  • Transendothelial migration

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Nickel, R., Beck, L. A., Stellato, C., & Schleimer, R. P. (1999). Chemokines and allergic disease. The Journal of Allergy and Clinical Immunology, 104(4 I), 723-742.