Abstract
Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compared these profiles to those of TCL-generated in response to tetanus toxoid (TT). Expression of CXCR6 and CXCR3 on TCL was significantly positively correlated with IFNγ, and inversely correlated with IL-5 production. TT TCL had significantly higher expression of CCR7-/CD45RA- T effector memory (Tem) cells than MBP TCL. However, in MBP-specific TCL, CXCR6 was found to be the best marker of conversion to the Tem phenotype. CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS).
Original language | English (US) |
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Pages (from-to) | 96-105 |
Number of pages | 10 |
Journal | Journal of Neuroimmunology |
Volume | 127 |
Issue number | 1-2 |
DOIs | |
State | Published - 2002 |
Keywords
- Chemokine receptors
- MBP
- Multiple sclerosis
- Th1/Th2
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology