Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNγ-producing effector cells

Peter A. Calabresi; Sung Hae Yun; Rameeza Allie; Katharine A. Whartenby

doi:10.1016/S0165-5728(02)00106-6

Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNγ-producing effector cells

Peter A. Calabresi, Sung Hae Yun, Rameeza Allie, Katharine A. Whartenby

School of Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compared these profiles to those of TCL-generated in response to tetanus toxoid (TT). Expression of CXCR6 and CXCR3 on TCL was significantly positively correlated with IFNγ, and inversely correlated with IL-5 production. TT TCL had significantly higher expression of CCR7^-/CD45RA^- T effector memory (Tem) cells than MBP TCL. However, in MBP-specific TCL, CXCR6 was found to be the best marker of conversion to the Tem phenotype. CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS).

Original language	English (US)
Pages (from-to)	96-105
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	127
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(02)00106-6
State	Published - 2002

Keywords

Chemokine receptors
MBP
Multiple sclerosis
Th1/Th2

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/S0165-5728(02)00106-6

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title = "Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNγ-producing effector cells",

abstract = "Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compared these profiles to those of TCL-generated in response to tetanus toxoid (TT). Expression of CXCR6 and CXCR3 on TCL was significantly positively correlated with IFNγ, and inversely correlated with IL-5 production. TT TCL had significantly higher expression of CCR7-/CD45RA- T effector memory (Tem) cells than MBP TCL. However, in MBP-specific TCL, CXCR6 was found to be the best marker of conversion to the Tem phenotype. CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS).",

keywords = "Chemokine receptors, MBP, Multiple sclerosis, Th1/Th2",

author = "Calabresi, {Peter A.} and Yun, {Sung Hae} and Rameeza Allie and Whartenby, {Katharine A.}",

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T2 - CXCR6 is a marker of IFNγ-producing effector cells

AU - Calabresi, Peter A.

AU - Yun, Sung Hae

AU - Allie, Rameeza

AU - Whartenby, Katharine A.

PY - 2002

Y1 - 2002

N2 - Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compared these profiles to those of TCL-generated in response to tetanus toxoid (TT). Expression of CXCR6 and CXCR3 on TCL was significantly positively correlated with IFNγ, and inversely correlated with IL-5 production. TT TCL had significantly higher expression of CCR7-/CD45RA- T effector memory (Tem) cells than MBP TCL. However, in MBP-specific TCL, CXCR6 was found to be the best marker of conversion to the Tem phenotype. CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS).

AB - Cytokine-polarized T cells have distinct chemokine receptor (CKR) expression patterns associated with their cytokine secretion profiles. In order to investigate this paradigm in autoreactive human T cells, we have determined the CKR expression pattern of myelin basic protein (MBP)-reactive T cell lines (TCL) and compared these profiles to those of TCL-generated in response to tetanus toxoid (TT). Expression of CXCR6 and CXCR3 on TCL was significantly positively correlated with IFNγ, and inversely correlated with IL-5 production. TT TCL had significantly higher expression of CCR7-/CD45RA- T effector memory (Tem) cells than MBP TCL. However, in MBP-specific TCL, CXCR6 was found to be the best marker of conversion to the Tem phenotype. CXCR6 and CXCR3 are likely to be important in the migration of effector memory T cells in Th1-mediated inflammatory diseases such as multiple sclerosis (MS).

KW - Chemokine receptors

KW - MBP

KW - Multiple sclerosis

KW - Th1/Th2

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Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNγ-producing effector cells

Abstract

Keywords

ASJC Scopus subject areas

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