TY - JOUR
T1 - Chemokine receptor expression by leukemic T cells of cutaneous T-cell lymphoma
T2 - Clinical and histopathological correlations
AU - Capriotti, Elisabetta
AU - Vonderheid, Eric C.
AU - Thoburn, Christopher J.
AU - Bright, Emilie C.
AU - Hess, Allan D.
N1 - Funding Information:
This work was supported by the Leonard and Ruth Levene Skin Research Fund and grant CA15396 from the National Cancer Institute, National Institutes of Health.
PY - 2007/12
Y1 - 2007/12
N2 - Chemokine receptors expressed by normal and neoplastic lymphocytes provide an important mechanism for cells to traffic into the skin and skin-associated lymph nodes. The goal of this study was to correlate chemokine receptor and CD62L expression by circulating neoplastic T cells with the clinical and pathological findings of the leukemic phase of cutaneous T-cell lymphoma, primarily Sézary syndrome (SS). Chemokine receptor mRNA transcripts were found in the majority of leukemic cells for CCR1, CCR4, CCR7, CCR10, CXCR3, and CD62L and in 20-50% of the samples for CXCR5. In patients with SS, relatively high expression levels of CCR7 and CCR10 by circulating neoplastic T cells correlated with epidermotropism, CXCR5 expression correlated with density of the dermal infiltrate, and CD62L correlated with extent of lymphadenopathy. Of note, CXCR5 expression and a dense dermal infiltrate correlated with a poor prognosis. The chemokine receptor profile supports the concept that neoplastic T cells are central memory T cells, and that CCR10 and CD62L play a fundamental role respectively in epidermotropism and lymphadenopathy that is observed in SS.
AB - Chemokine receptors expressed by normal and neoplastic lymphocytes provide an important mechanism for cells to traffic into the skin and skin-associated lymph nodes. The goal of this study was to correlate chemokine receptor and CD62L expression by circulating neoplastic T cells with the clinical and pathological findings of the leukemic phase of cutaneous T-cell lymphoma, primarily Sézary syndrome (SS). Chemokine receptor mRNA transcripts were found in the majority of leukemic cells for CCR1, CCR4, CCR7, CCR10, CXCR3, and CD62L and in 20-50% of the samples for CXCR5. In patients with SS, relatively high expression levels of CCR7 and CCR10 by circulating neoplastic T cells correlated with epidermotropism, CXCR5 expression correlated with density of the dermal infiltrate, and CD62L correlated with extent of lymphadenopathy. Of note, CXCR5 expression and a dense dermal infiltrate correlated with a poor prognosis. The chemokine receptor profile supports the concept that neoplastic T cells are central memory T cells, and that CCR10 and CD62L play a fundamental role respectively in epidermotropism and lymphadenopathy that is observed in SS.
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U2 - 10.1038/sj.jid.5700916
DO - 10.1038/sj.jid.5700916
M3 - Article
C2 - 17597825
AN - SCOPUS:36248929355
SN - 0022-202X
VL - 127
SP - 2882
EP - 2892
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 12
ER -