Chemokine GRO1 and the spatial and temporal regulation of oligodendrocyte precursor proliferation

Shenandoah Robinson, Linda A. Franic

Research output: Contribution to journalArticlepeer-review

Abstract

Oligodendrocyte precursor proliferation is precisely regulated spatially and temporally during development to allow optimal myelination of the central nervous system (CNS). We propose that a paracrine regulatory pathway involving the chemokine GRO1 and platelet-derived growth factor (PDGF) permit local control of precursor proliferation in the brain. GRO1, PDGF, and their receptors act synergistically to precisely regulate oligodendrocyte precursor proliferation in vitro and in vivo in the rat CNS. The nature of the paracrine regulatory loop with astrocyte and neuronal GRO1 expression in a pattern that is closely correlated with PDGFαR+ oligodendrocyte precursors suggests that the GRO1/PDGF regulatory mechanism provides local control of oligodendrocyte precursor proliferation during development.

Original languageEnglish (US)
Pages (from-to)338-345
Number of pages8
JournalDevelopmental Neuroscience
Volume23
Issue number4-5
DOIs
StatePublished - Dec 1 2001
Externally publishedYes

Keywords

  • Chemokine
  • Oligodendrocyte precursors
  • Proliferation
  • WCXCR2
  • WDevelopment
  • WGRO1

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

Fingerprint Dive into the research topics of 'Chemokine GRO1 and the spatial and temporal regulation of oligodendrocyte precursor proliferation'. Together they form a unique fingerprint.

Cite this