TY - JOUR
T1 - Chemoattractant signaling in Dictyostelium
T2 - Adaptation and amplification
AU - Iglesias, Pablo A.
PY - 2012/2/28
Y1 - 2012/2/28
N2 - The social amoebae Dictyostelium discoideum has long proved a powerful model organism for studying how cells sense and interpret chemoattractant gradients. Because of the rich behavior observed in its response to chemoattractants, as well as the complex nature of the signaling pathways involved, this research has attracted and benefited from the use of theoretical models. Recent quantitative experiments provide support for a popular model: the local excitation, global inhibition mechanism of gradient sensing. Here, I discuss these findings and suggest some important open problems.
AB - The social amoebae Dictyostelium discoideum has long proved a powerful model organism for studying how cells sense and interpret chemoattractant gradients. Because of the rich behavior observed in its response to chemoattractants, as well as the complex nature of the signaling pathways involved, this research has attracted and benefited from the use of theoretical models. Recent quantitative experiments provide support for a popular model: the local excitation, global inhibition mechanism of gradient sensing. Here, I discuss these findings and suggest some important open problems.
UR - http://www.scopus.com/inward/record.url?scp=84857774333&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857774333&partnerID=8YFLogxK
U2 - 10.1126/scisignal.2002897
DO - 10.1126/scisignal.2002897
M3 - Review article
C2 - 22375054
AN - SCOPUS:84857774333
VL - 5
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
SN - 1937-9145
IS - 213
M1 - pe8
ER -