Chemistry, biology, and QSAR studies of substituted biaryl hydroxamates and mercaptoacetamides as HDAC inhibitors - Nanomolar-potency inhibitors of pancreatic cancer cell growth

Alan P. Kozikowski, Yufeng Chen, Arsen M. Gaysin, Doris N. Savoy, Daniel D. Billadeau, Ki Hwan Kim

Research output: Contribution to journalArticle

Abstract

The histone deacetylases (HDACs) are able to regulate gene expression, and inhibitors of the HDACs (HDACIs) hold promise in the treatment of cancer as well as a variety of neurodegenerative diseases. To investigate the potential for isoform selectivity in the inhibition of HDACs, we prepared a small series of 2,4′-diaminobiphenyl ligands functionalized at the para-amino group with an appendage containing either a hydroxamate or a mercaptoacetamide group and coupled to an amino acid residue at the ortho-amino group. A smaller series of substituted phenylthiazoles was also explored. Some of these newly synthesized ligands show low-nanomolar potency in HDAC inhibition assays and display micromolar to low-nanomolar IC50 values in tests against five pancreatic cancer cell lines. The isoform selectivity of these ligands for class I HDACs (HDAC1-3 and 8) and class IIb HDACs (HDAC6 and 10) together with QSAR studies of their correlation with lipophilicity are presented. Of particular interest is the selectivity of the mercaptoacetamides for HDAC6.

Original languageEnglish (US)
Pages (from-to)487-501
Number of pages15
JournalChemMedChem
Volume3
Issue number3
DOIs
StatePublished - Mar 14 2008

Keywords

  • Biphenyls
  • HDAC inhibitors
  • Isoform selectivity
  • Pancreatic cancer
  • Phenylthiazoles

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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