Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors

Bin Chen, Pavel A. Petukhov, Mira Jung, Alfredo Velena, Elena Eliseeva, Anatoly Dritschilo, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

Abstract

A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA.

Original languageEnglish (US)
Pages (from-to)1389-1392
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number5
DOIs
StatePublished - Mar 1 2005

Keywords

  • HDAC
  • Histone deacetylase inhibitor
  • Mercaptoacetamide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors'. Together they form a unique fingerprint.

Cite this