Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors

Bin Chen; Pavel A. Petukhov; Mira Jung; Alfredo Velena; Elena Eliseeva; Anatoly Dritschilo; Alan P. Kozikowski

doi:10.1016/j.bmcl.2005.01.006

Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors

Bin Chen, Pavel A. Petukhov, Mira Jung, Alfredo Velena, Elena Eliseeva, Anatoly Dritschilo, Alan P. Kozikowski

School of Medicine

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA.

Original language	English (US)
Pages (from-to)	1389-1392
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2005.01.006
State	Published - Mar 1 2005

Keywords

HDAC
Histone deacetylase inhibitor
Mercaptoacetamide

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2005.01.006

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title = "Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors",

abstract = "A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA.",

keywords = "HDAC, Histone deacetylase inhibitor, Mercaptoacetamide",

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AU - Jung, Mira

AU - Velena, Alfredo

AU - Eliseeva, Elena

AU - Dritschilo, Anatoly

AU - Kozikowski, Alan P.

PY - 2005/3/1

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KW - Histone deacetylase inhibitor

KW - Mercaptoacetamide

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Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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