Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP4 and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP4 - potent 1d-1,4,5-InsP3-like calcium mobilizing analogues

Alan P. Kozikowski; Abdul H. Fauq; Robert A. Wilcox; Stefan R. Nahorski

doi:10.1016/0960-894X(95)00210-K

Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP₄ and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP₄ - potent 1d-1,4,5-InsP₃-like calcium mobilizing analogues

Alan P. Kozikowski, Abdul H. Fauq, Robert A. Wilcox, Stefan R. Nahorski

School of Medicine

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15 Scopus citations

Abstract

Syntheses of optically pure 1d-3-F-2,4,5-InsP₃, 1d-3-F-1,2,4,5-InsP₄, and 1d-1,2,4,5-InsP₄ are reported starting from l-quebrachitol. The latter two compounds are shown to be nearly equipotent to 1d-1,4,5-InsP₃ in both binding and calcium release experiments.

Original language	English (US)
Pages (from-to)	1295-1300
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	5
Issue number	12
DOIs	https://doi.org/10.1016/0960-894X(95)00210-K
State	Published - Jun 22 1995

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0960-894X(95)00210-K

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Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP₄ and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP₄ - potent 1d-1,4,5-InsP₃-like calcium mobilizing analogues. / Kozikowski, Alan P.; Fauq, Abdul H.; Wilcox, Robert A. et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 5, No. 12, 22.06.1995, p. 1295-1300.

Research output: Contribution to journal › Article › peer-review

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abstract = "Syntheses of optically pure 1d-3-F-2,4,5-InsP3, 1d-3-F-1,2,4,5-InsP4, and 1d-1,2,4,5-InsP4 are reported starting from l-quebrachitol. The latter two compounds are shown to be nearly equipotent to 1d-1,4,5-InsP3 in both binding and calcium release experiments.",

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AU - Kozikowski, Alan P.

AU - Fauq, Abdul H.

AU - Wilcox, Robert A.

AU - Nahorski, Stefan R.

PY - 1995/6/22

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AB - Syntheses of optically pure 1d-3-F-2,4,5-InsP3, 1d-3-F-1,2,4,5-InsP4, and 1d-1,2,4,5-InsP4 are reported starting from l-quebrachitol. The latter two compounds are shown to be nearly equipotent to 1d-1,4,5-InsP3 in both binding and calcium release experiments.

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Chemical synthesis and biological evaluation of 1d-1,2,4,5-InsP₄ and its 3-fluorinated counterpart 1d-3-F-1,2,4,5-InsP₄ - potent 1d-1,4,5-InsP₃-like calcium mobilizing analogues

Abstract

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