Chemical priming for spinal cord injury: A review of the literature part II-potential therapeutics

Martin M. Mortazavi, Ketan Verma, Aman Deep, Fatemeh B. Esfahani, Patrick R. Pritchard, R. Shane Tubbs, Nicholas Theodore

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Spinal cord injury is a complex cascade of reactions secondary to the initial mechanical trauma that puts into action the innate properties of the injured cells, the circulatory, inflammatory, and chemical status around them, into a non-permissive and destructive environment for neuronal function and regeneration. Priming means putting a cell, in a state of "arousal" towards better function. Priming can be mechanical as trauma is known to enhance activity in cells. Materials and methods: A comprehensive review of the literature was performed to better understand the possible chemical primers used for spinal cord injuries. Conclusions: Taken together, many studies have shown various promising results using the substances outlined herein for treating SCI.

Original languageEnglish (US)
Pages (from-to)1307-1316
Number of pages10
JournalChild's Nervous System
Volume27
Issue number8
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

Keywords

  • Experimental
  • Injury
  • Spinal cord
  • Trauma
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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