TY - JOUR
T1 - Chemical priming for spinal cord injury
T2 - A review of the literature part II-potential therapeutics
AU - Mortazavi, Martin M.
AU - Verma, Ketan
AU - Deep, Aman
AU - Esfahani, Fatemeh B.
AU - Pritchard, Patrick R.
AU - Tubbs, R. Shane
AU - Theodore, Nicholas
PY - 2011/8
Y1 - 2011/8
N2 - Introduction: Spinal cord injury is a complex cascade of reactions secondary to the initial mechanical trauma that puts into action the innate properties of the injured cells, the circulatory, inflammatory, and chemical status around them, into a non-permissive and destructive environment for neuronal function and regeneration. Priming means putting a cell, in a state of "arousal" towards better function. Priming can be mechanical as trauma is known to enhance activity in cells. Materials and methods: A comprehensive review of the literature was performed to better understand the possible chemical primers used for spinal cord injuries. Conclusions: Taken together, many studies have shown various promising results using the substances outlined herein for treating SCI.
AB - Introduction: Spinal cord injury is a complex cascade of reactions secondary to the initial mechanical trauma that puts into action the innate properties of the injured cells, the circulatory, inflammatory, and chemical status around them, into a non-permissive and destructive environment for neuronal function and regeneration. Priming means putting a cell, in a state of "arousal" towards better function. Priming can be mechanical as trauma is known to enhance activity in cells. Materials and methods: A comprehensive review of the literature was performed to better understand the possible chemical primers used for spinal cord injuries. Conclusions: Taken together, many studies have shown various promising results using the substances outlined herein for treating SCI.
KW - Experimental
KW - Injury
KW - Spinal cord
KW - Trauma
KW - Treatment
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U2 - 10.1007/s00381-010-1365-x
DO - 10.1007/s00381-010-1365-x
M3 - Review article
C2 - 21174102
AN - SCOPUS:79960901959
SN - 0256-7040
VL - 27
SP - 1307
EP - 1316
JO - Child's Nervous System
JF - Child's Nervous System
IS - 8
ER -