Chemical medicine: Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors

Alan P. Kozikowski, Sheela K. Chellappan, Yingxian Xiao, Krishna Mohan Bajjuri, Hongbin Yuan, Kenneth J. Kellar, Pavel A. Petukhov

Research output: Contribution to journalArticlepeer-review

Abstract

Neuronal nicotinic acetylcholine receptors are widely distributed in the central and peripheral nervous systems. Several lines of evidence suggest that the α4β2 nAChRs mediate addiction to nicotine in tobacco smoking. Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors were synthesized and may be of use in smoking cessation. (Chemical Equation Presented).

Original languageEnglish (US)
Pages (from-to)1157-1161
Number of pages5
JournalChemMedChem
Volume2
Issue number8
DOIs
StatePublished - Aug 13 2007

Keywords

  • Natural products
  • Nicotinic ligands
  • Smoking cessation
  • Subtype selectivity
  • α4β2 receptor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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