Chemical medicine: Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors

Alan P. Kozikowski; Sheela K. Chellappan; Yingxian Xiao; Krishna Mohan Bajjuri; Hongbin Yuan; Kenneth J. Kellar; Pavel A. Petukhov

doi:10.1002/cmdc.200700073

Chemical medicine: Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors

Alan P. Kozikowski, Sheela K. Chellappan, Yingxian Xiao, Krishna Mohan Bajjuri, Hongbin Yuan, Kenneth J. Kellar, Pavel A. Petukhov

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Neuronal nicotinic acetylcholine receptors are widely distributed in the central and peripheral nervous systems. Several lines of evidence suggest that the α4β2 nAChRs mediate addiction to nicotine in tobacco smoking. Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors were synthesized and may be of use in smoking cessation. (Chemical Equation Presented).

Original language	English (US)
Pages (from-to)	1157-1161
Number of pages	5
Journal	ChemMedChem
Volume	2
Issue number	8
DOIs	https://doi.org/10.1002/cmdc.200700073
State	Published - Aug 13 2007
Externally published	Yes

Keywords

Natural products
Nicotinic ligands
Smoking cessation
Subtype selectivity
α4β2 receptor

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics(all)
Organic Chemistry

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10.1002/cmdc.200700073

Cite this

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abstract = "Neuronal nicotinic acetylcholine receptors are widely distributed in the central and peripheral nervous systems. Several lines of evidence suggest that the α4β2 nAChRs mediate addiction to nicotine in tobacco smoking. Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors were synthesized and may be of use in smoking cessation. (Chemical Equation Presented).",

keywords = "Natural products, Nicotinic ligands, Smoking cessation, Subtype selectivity, α4β2 receptor",

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T2 - Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors

AU - Kozikowski, Alan P.

AU - Chellappan, Sheela K.

AU - Xiao, Yingxian

AU - Bajjuri, Krishna Mohan

AU - Yuan, Hongbin

AU - Kellar, Kenneth J.

AU - Petukhov, Pavel A.

PY - 2007/8/13

Y1 - 2007/8/13

N2 - Neuronal nicotinic acetylcholine receptors are widely distributed in the central and peripheral nervous systems. Several lines of evidence suggest that the α4β2 nAChRs mediate addiction to nicotine in tobacco smoking. Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors were synthesized and may be of use in smoking cessation. (Chemical Equation Presented).

AB - Neuronal nicotinic acetylcholine receptors are widely distributed in the central and peripheral nervous systems. Several lines of evidence suggest that the α4β2 nAChRs mediate addiction to nicotine in tobacco smoking. Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors were synthesized and may be of use in smoking cessation. (Chemical Equation Presented).

KW - Natural products

KW - Nicotinic ligands

KW - Smoking cessation

KW - Subtype selectivity

KW - α4β2 receptor

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Chemical medicine: Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors

Abstract

Keywords

ASJC Scopus subject areas

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