Chemical mediators of migraine: Preclinical and clinical observations

Saurabh Gupta, Stephanie J. Nahas, B. Lee Peterlin

Research output: Contribution to journalReview articlepeer-review

Abstract

Migraine is a neurovascular disorder, and although the pathophysiology of migraine has not been fully delineated, much has been learned in the past 50 years. This knowledge has been accompanied by significant advancements in the way migraine is viewed as a disease process and in the development therapeutic options. In this review, we will focus on 4 mediators (nitric oxide, histamine, serotonin, and calcitonin gene-related peptide) which have significantly advanced our understanding of migraine as a disease entity. For each mediator we begin by reviewing the preclinical data linking it to migraine pathophysiology, first focusing on the vascular mechanisms, then the neuronal mechanisms. The preclinical data are then followed by a review of the clinical data which support each mediator's role in migraine and highlights the pharmacological agents which target these mediators for migraine therapy.

Original languageEnglish (US)
Pages (from-to)1029-1045
Number of pages17
JournalHeadache
Volume51
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • 5-HT
  • CGRP
  • NO
  • histamine
  • migraine

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Chemical mediators of migraine: Preclinical and clinical observations'. Together they form a unique fingerprint.

Cite this