Chemical exchange saturation transfer MR imaging of Parkinson’s disease at 3 Tesla

Chunmei Li, Shuai Peng, Rui Wang, Haibo Chen, Wen Su, Xuna Zhao, Jinyuan Zhou, Min Chen

Research output: Contribution to journalArticle

Abstract

Results: Total CEST signal between the offsets of 0 and 4 ppm in the substantia nigra was significantly lower in PD patients than in normal controls (P = 0.006), which could be associated with the loss of dopaminergic neurons. Protein-based CEST imaging signals at the offset of 3.5 ppm in the globus pallidus, putamen and caudate were significantly increased in PD patients, compared to normal controls (P <0.001, P = 0.003, P <0.001, respectively).

Conclusions: CEST imaging signals could potentially serve as imaging biomarkers to aid in the non-invasive molecular diagnosis of PD.

Objectives: To demonstrate the feasibility of using chemical exchange saturation transfer (CEST) imaging to detect Parkinson’s disease (PD) in patients at 3 Tesla.

Methods: Twenty-seven PD patients (17 men and 10 women; age range, 54–77 years) and 22 age-matched normal controls (13 men and 9 women; age range, 55–73 years) were examined on a 3-Tesla MRI system. Magnetization transfer spectra with 31 different frequency offsets (−6 to 6 ppm) were acquired at two transverse slices of the head, including the basal ganglia and midbrain. One-way analysis of variance tests was used to compare the differences in CEST imaging signals between PD patients and normal controls.

Original languageEnglish (US)
Pages (from-to)2631-2639
Number of pages9
JournalEuropean Radiology
Volume24
Issue number10
DOIs
StatePublished - 2014

Fingerprint

Parkinson Disease
Globus Pallidus
Dopaminergic Neurons
Putamen
Substantia Nigra
Mesencephalon
Basal Ganglia
Parkinson disease 3
Analysis of Variance
Biomarkers
Head
Proteins

Keywords

  • Amide proton transfer
  • Biomarker
  • Chemical exchange saturation transfer
  • Molecular imaging
  • Parkinson’s disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Li, C., Peng, S., Wang, R., Chen, H., Su, W., Zhao, X., ... Chen, M. (2014). Chemical exchange saturation transfer MR imaging of Parkinson’s disease at 3 Tesla. European Radiology, 24(10), 2631-2639. https://doi.org/10.1007/s00330-014-3241-7

Chemical exchange saturation transfer MR imaging of Parkinson’s disease at 3 Tesla. / Li, Chunmei; Peng, Shuai; Wang, Rui; Chen, Haibo; Su, Wen; Zhao, Xuna; Zhou, Jinyuan; Chen, Min.

In: European Radiology, Vol. 24, No. 10, 2014, p. 2631-2639.

Research output: Contribution to journalArticle

Li, C, Peng, S, Wang, R, Chen, H, Su, W, Zhao, X, Zhou, J & Chen, M 2014, 'Chemical exchange saturation transfer MR imaging of Parkinson’s disease at 3 Tesla', European Radiology, vol. 24, no. 10, pp. 2631-2639. https://doi.org/10.1007/s00330-014-3241-7
Li, Chunmei ; Peng, Shuai ; Wang, Rui ; Chen, Haibo ; Su, Wen ; Zhao, Xuna ; Zhou, Jinyuan ; Chen, Min. / Chemical exchange saturation transfer MR imaging of Parkinson’s disease at 3 Tesla. In: European Radiology. 2014 ; Vol. 24, No. 10. pp. 2631-2639.
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