Chemical exchange saturation transfer MR imaging of articular cartilage glycosaminoglycans at 3T: Accuracy of B0 Field Inhomogeneity corrections with gradient echo method

Wenbo Wei, Guang Jia, David Flanigan, Jinyuan Zhou, Michael V. Knopp

Research output: Contribution to journalArticle

Abstract

Glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) is an important molecular MRI methodology developed to assess changes in cartilage GAG concentrations. The correction for B0 field inhomogeneity is technically crucial in gagCEST imaging. This study evaluates the accuracy of the B0 estimation determined by the dual gradient echo method and the effect on gagCEST measurements. The results were compared with those from the commonly used z-spectrum method. Eleven knee patients and three healthy volunteers were scanned. Dual gradient echo B0 maps with different {increment}TE values (1, 2, 4, 8, and 10ms) were acquired. The asymmetry of the magnetization transfer ratio at 1ppm offset referred to the bulk water frequency, MTRasym(1ppm), was used to quantify cartilage GAG levels. The B0 shifts for all knee patients using the z-spectrum and dual gradient echo methods are strongly correlated for all {increment}TE values used (r=0.997 to 0.786, corresponding to {increment}TE=10 to 1ms). The corrected MTRasym(1ppm) values using the z-spectrum method (1.34%±0.74%) highly agree only with those using the dual gradient echo methods with {increment}TE=10ms (1.72%±0.80%; r=0.924) and 8ms (1.50%±0.82%; r=0.712). The dual gradient echo method with longer {increment}TE values (more than 8ms) has an excellent correlation with the z-spectrum method for gagCEST imaging at 3T.

Original languageEnglish (US)
Pages (from-to)41-47
Number of pages7
JournalMagnetic Resonance Imaging
Volume32
Issue number1
DOIs
StatePublished - Jan 2014

Fingerprint

Cartilage
Articular Cartilage
Glycosaminoglycans
Imaging techniques
Knee
Magnetic resonance imaging
Magnetization
Healthy Volunteers
Water

Keywords

  • B field inhomogeneity
  • Chemical exchange saturation transfer
  • Dual gradient echo method
  • Glycosaminoglycan
  • Knee osteoarthritis

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering

Cite this

Chemical exchange saturation transfer MR imaging of articular cartilage glycosaminoglycans at 3T : Accuracy of B0 Field Inhomogeneity corrections with gradient echo method. / Wei, Wenbo; Jia, Guang; Flanigan, David; Zhou, Jinyuan; Knopp, Michael V.

In: Magnetic Resonance Imaging, Vol. 32, No. 1, 01.2014, p. 41-47.

Research output: Contribution to journalArticle

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abstract = "Glycosaminoglycan Chemical Exchange Saturation Transfer (gagCEST) is an important molecular MRI methodology developed to assess changes in cartilage GAG concentrations. The correction for B0 field inhomogeneity is technically crucial in gagCEST imaging. This study evaluates the accuracy of the B0 estimation determined by the dual gradient echo method and the effect on gagCEST measurements. The results were compared with those from the commonly used z-spectrum method. Eleven knee patients and three healthy volunteers were scanned. Dual gradient echo B0 maps with different {increment}TE values (1, 2, 4, 8, and 10ms) were acquired. The asymmetry of the magnetization transfer ratio at 1ppm offset referred to the bulk water frequency, MTRasym(1ppm), was used to quantify cartilage GAG levels. The B0 shifts for all knee patients using the z-spectrum and dual gradient echo methods are strongly correlated for all {increment}TE values used (r=0.997 to 0.786, corresponding to {increment}TE=10 to 1ms). The corrected MTRasym(1ppm) values using the z-spectrum method (1.34{\%}±0.74{\%}) highly agree only with those using the dual gradient echo methods with {increment}TE=10ms (1.72{\%}±0.80{\%}; r=0.924) and 8ms (1.50{\%}±0.82{\%}; r=0.712). The dual gradient echo method with longer {increment}TE values (more than 8ms) has an excellent correlation with the z-spectrum method for gagCEST imaging at 3T.",
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