Chemical enhancement of tumor immunogenicity

A. E. Eggers, C. A. Hibbard, C. I. Civin, J. R. Wunderlich

Research output: Contribution to journalArticle

Abstract

C57BL/6 spleen cells immunized in vitro against syngeneic methylcholanthrene-induced sarcoma cells (MC-1 cells) modified with various chemical reagents show cytotoxic activity against unmodified MC-1 cells in a short-term 51Cr release assay, whereas unmodified MC-1 cells are nonimmunogenic. The effector cells cross-react widely with many other fibroblastic and epithelioid tumors, even those that are not H-2 matched, as well as with some nonneoplastic cells. Priming mice in vivo with a hapten leads to enhanced anti-tumor cytotoxicity developed by spleen cells from these mice immunized in vitro against tumor cells modified with the same hapten. Cytotoxic activity is largely, but not completely, removed by treatment with anti-θ serum and C. The existence of suppressor cells that can inhibit an anti-tumor response is demonstrated in in vitro immunizations of mixtures of spleen cells from normal mice and mice primed with mitomycin-treated cells, the latter suppressing the former.

Original languageEnglish (US)
Pages (from-to)1737-1744
Number of pages8
JournalJournal of Immunology
Volume125
Issue number4
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    Eggers, A. E., Hibbard, C. A., Civin, C. I., & Wunderlich, J. R. (1980). Chemical enhancement of tumor immunogenicity. Journal of Immunology, 125(4), 1737-1744.