TY - JOUR
T1 - Chemical diabetes in childhood. Integrated concentrations of glucose, insulin, and growth hormone
AU - Winter, R. J.
AU - Plotnick, L. P.
AU - Thompson, R. G.
PY - 1978
Y1 - 1978
N2 - Children and adolescents with varying degrees of glucose intolerance were studied with constant, blood withdrawal methods, and concentrations of glucose, insulin, and growth hormone were evaluated during a normal twenty-four-hour routine. Integrated concentrations of glucose and insulin in children with chemical diabetes were normal despite abnormal oral glucose-tolerance tests. All but two insulin-dependent diabetics had elevated integrated concentrations of growth hormone, as did some but not all chemical diabetics. Three of four mildly ketoacidotic individuals with newly diagnosed diabetes, who were studied before insulin therapy, had normal growth hormone-integrated concentrations. These data differentiate pharmacologic and physiologic assessments of carbohydrate homeostasis, as they support the concept that elevated growth hormone concentrations may not be a direct result of poor diabetic control.
AB - Children and adolescents with varying degrees of glucose intolerance were studied with constant, blood withdrawal methods, and concentrations of glucose, insulin, and growth hormone were evaluated during a normal twenty-four-hour routine. Integrated concentrations of glucose and insulin in children with chemical diabetes were normal despite abnormal oral glucose-tolerance tests. All but two insulin-dependent diabetics had elevated integrated concentrations of growth hormone, as did some but not all chemical diabetics. Three of four mildly ketoacidotic individuals with newly diagnosed diabetes, who were studied before insulin therapy, had normal growth hormone-integrated concentrations. These data differentiate pharmacologic and physiologic assessments of carbohydrate homeostasis, as they support the concept that elevated growth hormone concentrations may not be a direct result of poor diabetic control.
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U2 - 10.2337/diab.27.9.909
DO - 10.2337/diab.27.9.909
M3 - Article
C2 - 567604
AN - SCOPUS:0018078244
SN - 0012-1797
VL - 27
SP - 909
EP - 915
JO - Diabetes
JF - Diabetes
IS - 9
ER -