Chemical diabetes in childhood. Integrated concentrations of glucose, insulin, and growth hormone

R. J. Winter, L. P. Plotnick, R. G. Thompson

Research output: Contribution to journalArticle

Abstract

Children and adolescents with varying degrees of glucose intolerance were studied with constant, blood withdrawal methods, and concentrations of glucose, insulin, and growth hormone were evaluated during a normal twenty-four-hour routine. Integrated concentrations of glucose and insulin in children with chemical diabetes were normal despite abnormal oral glucose-tolerance tests. All but two insulin-dependent diabetics had elevated integrated concentrations of growth hormone, as did some but not all chemical diabetics. Three of four mildly ketoacidotic individuals with newly diagnosed diabetes, who were studied before insulin therapy, had normal growth hormone-integrated concentrations. These data differentiate pharmacologic and physiologic assessments of carbohydrate homeostasis, as they support the concept that elevated growth hormone concentrations may not be a direct result of poor diabetic control.

Original languageEnglish (US)
Pages (from-to)909-915
Number of pages7
JournalDiabetes
Volume27
Issue number9
StatePublished - 1978
Externally publishedYes

Fingerprint

Growth Hormone
Insulin
Glucose
Glucose Intolerance
Glucose Tolerance Test
Homeostasis
Carbohydrates
Therapeutics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Winter, R. J., Plotnick, L. P., & Thompson, R. G. (1978). Chemical diabetes in childhood. Integrated concentrations of glucose, insulin, and growth hormone. Diabetes, 27(9), 909-915.

Chemical diabetes in childhood. Integrated concentrations of glucose, insulin, and growth hormone. / Winter, R. J.; Plotnick, L. P.; Thompson, R. G.

In: Diabetes, Vol. 27, No. 9, 1978, p. 909-915.

Research output: Contribution to journalArticle

Winter, RJ, Plotnick, LP & Thompson, RG 1978, 'Chemical diabetes in childhood. Integrated concentrations of glucose, insulin, and growth hormone', Diabetes, vol. 27, no. 9, pp. 909-915.
Winter, R. J. ; Plotnick, L. P. ; Thompson, R. G. / Chemical diabetes in childhood. Integrated concentrations of glucose, insulin, and growth hormone. In: Diabetes. 1978 ; Vol. 27, No. 9. pp. 909-915.
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