Chemical burns of the eye: The role of retinal injury and new therapeutic possibilities

Claes H. Dohlman, Fabiano Cade, Caio V. Regatieri, Chengxin Zhou, Fengyang Lei, Alja Crnej, Mona Harissi-Dagher, Marie Claude Robert, George N. Papaliodis, Dongfeng Chen, James V. Aquavella, Esen K Akpek, Anthony J. Aldave, Kimberly C. Sippel, Donald J. D'Amico, Jan G. Dohlman, Per Fagerholm, Liqiang Wang, Lucy Q. Shen, Miguel González-AndradesJames Chodosh, Kenneth R. Kenyon, C. Stephen Foster, Roberto Pineda, Samir Melki, Kathryn A. Colby, Joseph B. Ciolino, Demetrios G. Vavvas, Shigeru Kinoshita, Reza Dana, Eleftherios I. Paschalis

Research output: Contribution to journalArticle

Abstract

Purpose: To propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases. Methods: Recent laboratory and clinical data on the biology and treatment of chemical burns are analyzed. Results: Corneal blindness from chemical burns can now be successfully treated with a keratoprosthesis, on immediate and intermediate bases. Long term outcomes, however, are hampered by early retinal damage causing glaucoma. New data suggest that rapid diffusion of inflammatory cytokines posteriorly (TNF-α, etc) can severely damage the ganglion cells. Prompt anti-TNF-α treatment is markedly neuroprotective. Long term profound reduction of the intraocular pressure is also vital. Conclusion: A new regimen, in addition to standard treatment, for severe chemical burns is proposed. This involves tumor necrosis factor alpha (TNF-α) inhibition promptly after the accident (primarily for retinal neuroprotection), prophylactic maximal lowering of the intraocular pressure (starting immediately), and keratoprosthesis implantation in a later quiet state.

Original languageEnglish (US)
Pages (from-to)248-251
Number of pages4
JournalCornea
Volume37
Issue number2
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Chemical Burns
Tumor Necrosis Factor-alpha
Wounds and Injuries
Intraocular Pressure
Blindness
Therapeutics
Ganglia
Glaucoma
Accidents
Cytokines

Keywords

  • Chemical burns
  • Glaucoma
  • Infliximab
  • Keratoprosthesis
  • Retinal protection
  • Tumor necrosis factor alpha

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Dohlman, C. H., Cade, F., Regatieri, C. V., Zhou, C., Lei, F., Crnej, A., ... Paschalis, E. I. (2018). Chemical burns of the eye: The role of retinal injury and new therapeutic possibilities. Cornea, 37(2), 248-251. https://doi.org/10.1097/ICO.0000000000001438

Chemical burns of the eye : The role of retinal injury and new therapeutic possibilities. / Dohlman, Claes H.; Cade, Fabiano; Regatieri, Caio V.; Zhou, Chengxin; Lei, Fengyang; Crnej, Alja; Harissi-Dagher, Mona; Robert, Marie Claude; Papaliodis, George N.; Chen, Dongfeng; Aquavella, James V.; Akpek, Esen K; Aldave, Anthony J.; Sippel, Kimberly C.; D'Amico, Donald J.; Dohlman, Jan G.; Fagerholm, Per; Wang, Liqiang; Shen, Lucy Q.; González-Andrades, Miguel; Chodosh, James; Kenyon, Kenneth R.; Foster, C. Stephen; Pineda, Roberto; Melki, Samir; Colby, Kathryn A.; Ciolino, Joseph B.; Vavvas, Demetrios G.; Kinoshita, Shigeru; Dana, Reza; Paschalis, Eleftherios I.

In: Cornea, Vol. 37, No. 2, 01.01.2018, p. 248-251.

Research output: Contribution to journalArticle

Dohlman, CH, Cade, F, Regatieri, CV, Zhou, C, Lei, F, Crnej, A, Harissi-Dagher, M, Robert, MC, Papaliodis, GN, Chen, D, Aquavella, JV, Akpek, EK, Aldave, AJ, Sippel, KC, D'Amico, DJ, Dohlman, JG, Fagerholm, P, Wang, L, Shen, LQ, González-Andrades, M, Chodosh, J, Kenyon, KR, Foster, CS, Pineda, R, Melki, S, Colby, KA, Ciolino, JB, Vavvas, DG, Kinoshita, S, Dana, R & Paschalis, EI 2018, 'Chemical burns of the eye: The role of retinal injury and new therapeutic possibilities', Cornea, vol. 37, no. 2, pp. 248-251. https://doi.org/10.1097/ICO.0000000000001438
Dohlman CH, Cade F, Regatieri CV, Zhou C, Lei F, Crnej A et al. Chemical burns of the eye: The role of retinal injury and new therapeutic possibilities. Cornea. 2018 Jan 1;37(2):248-251. https://doi.org/10.1097/ICO.0000000000001438
Dohlman, Claes H. ; Cade, Fabiano ; Regatieri, Caio V. ; Zhou, Chengxin ; Lei, Fengyang ; Crnej, Alja ; Harissi-Dagher, Mona ; Robert, Marie Claude ; Papaliodis, George N. ; Chen, Dongfeng ; Aquavella, James V. ; Akpek, Esen K ; Aldave, Anthony J. ; Sippel, Kimberly C. ; D'Amico, Donald J. ; Dohlman, Jan G. ; Fagerholm, Per ; Wang, Liqiang ; Shen, Lucy Q. ; González-Andrades, Miguel ; Chodosh, James ; Kenyon, Kenneth R. ; Foster, C. Stephen ; Pineda, Roberto ; Melki, Samir ; Colby, Kathryn A. ; Ciolino, Joseph B. ; Vavvas, Demetrios G. ; Kinoshita, Shigeru ; Dana, Reza ; Paschalis, Eleftherios I. / Chemical burns of the eye : The role of retinal injury and new therapeutic possibilities. In: Cornea. 2018 ; Vol. 37, No. 2. pp. 248-251.
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AU - Zhou, Chengxin

AU - Lei, Fengyang

AU - Crnej, Alja

AU - Harissi-Dagher, Mona

AU - Robert, Marie Claude

AU - Papaliodis, George N.

AU - Chen, Dongfeng

AU - Aquavella, James V.

AU - Akpek, Esen K

AU - Aldave, Anthony J.

AU - Sippel, Kimberly C.

AU - D'Amico, Donald J.

AU - Dohlman, Jan G.

AU - Fagerholm, Per

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AU - González-Andrades, Miguel

AU - Chodosh, James

AU - Kenyon, Kenneth R.

AU - Foster, C. Stephen

AU - Pineda, Roberto

AU - Melki, Samir

AU - Colby, Kathryn A.

AU - Ciolino, Joseph B.

AU - Vavvas, Demetrios G.

AU - Kinoshita, Shigeru

AU - Dana, Reza

AU - Paschalis, Eleftherios I.

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