Characterizing the spatial distribution of microhemorrhages resulting from Traumatic Brain Injury (TBI)

Ningzhi Li, Yi Yu Chou, Navid Shiee, Leighton Chan, Dzung L. Pham, John A. Butman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study examines the spatial distribution of microhemorrhages defined using susceptibility weighted images (SWI) in 46 patients with Traumatic Brain Injury (TBI) and applying region of interest (ROI) analysis using a brain atlas. SWI and 3D T1-weighted images were acquired on a 3T clinical Siemens scanner. A neuroradiologist reviewed all SWI images and manually labeled all identified microhemorrhages. To characterize the spatial distribution of microhemorrhages in standard Montreal Neurological Institute (MNI) space, the T1-weighted images were nonlinearly registered to the MNI template. This transformation was then applied to the co-registered SWI images and to the microhemorrhage coordinates. The frequencies of microhemorrhages were determined in major structures from ROIs defined in the digital Talairach brain atlas and in white matter tracts defined using a diffusion tensor imaging atlas. A total of 629 microhemorrhages were found with an average of 22±42 (range=1-179) in the 24 positive TBI patients. Microhemorrhages mostly congregated around the periphery of the brain and were fairly symmetrically distributed, although a number were found in the corpus callosum. From Talairach ROI analysis, microhemorrhages were most prevalent in the frontal lobes (65.1%). Restricting the analysis to WM tracts, microhemorrhages were primarily found in the corpus callosum (56.9%).

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9038
ISBN (Print)9780819498311
DOIs
StatePublished - 2014
Externally publishedYes
EventMedical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
Duration: Feb 16 2014Feb 18 2014

Other

OtherMedical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego, CA
Period2/16/142/18/14

Fingerprint

brain damage
Atlases
Spatial distribution
Brain
spatial distribution
Corpus Callosum
Diffusion Tensor Imaging
Frontal Lobe
brain
magnetic permeability
Diffusion tensor imaging
Traumatic Brain Injury
lobes
scanners
templates
tensors

Keywords

  • Brain Atlas
  • Microhemorrhages
  • MNI space
  • Registration
  • SWI
  • Talairach ROI analysis
  • Traumatic Brain Injury

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Li, N., Chou, Y. Y., Shiee, N., Chan, L., Pham, D. L., & Butman, J. A. (2014). Characterizing the spatial distribution of microhemorrhages resulting from Traumatic Brain Injury (TBI). In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9038). [90381Q] SPIE. https://doi.org/10.1117/12.2043750

Characterizing the spatial distribution of microhemorrhages resulting from Traumatic Brain Injury (TBI). / Li, Ningzhi; Chou, Yi Yu; Shiee, Navid; Chan, Leighton; Pham, Dzung L.; Butman, John A.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9038 SPIE, 2014. 90381Q.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Li, N, Chou, YY, Shiee, N, Chan, L, Pham, DL & Butman, JA 2014, Characterizing the spatial distribution of microhemorrhages resulting from Traumatic Brain Injury (TBI). in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 9038, 90381Q, SPIE, Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, CA, United States, 2/16/14. https://doi.org/10.1117/12.2043750
Li N, Chou YY, Shiee N, Chan L, Pham DL, Butman JA. Characterizing the spatial distribution of microhemorrhages resulting from Traumatic Brain Injury (TBI). In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9038. SPIE. 2014. 90381Q https://doi.org/10.1117/12.2043750
Li, Ningzhi ; Chou, Yi Yu ; Shiee, Navid ; Chan, Leighton ; Pham, Dzung L. ; Butman, John A. / Characterizing the spatial distribution of microhemorrhages resulting from Traumatic Brain Injury (TBI). Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9038 SPIE, 2014.
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