Characterizing the spatial distribution of microhemorrhages resulting from Traumatic Brain Injury (TBI)

Ningzhi Li, Yi Yu Chou, Navid Shiee, Leighton Chan, Dzung L. Pham, John A. Butman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study examines the spatial distribution of microhemorrhages defined using susceptibility weighted images (SWI) in 46 patients with Traumatic Brain Injury (TBI) and applying region of interest (ROI) analysis using a brain atlas. SWI and 3D T1-weighted images were acquired on a 3T clinical Siemens scanner. A neuroradiologist reviewed all SWI images and manually labeled all identified microhemorrhages. To characterize the spatial distribution of microhemorrhages in standard Montreal Neurological Institute (MNI) space, the T1-weighted images were nonlinearly registered to the MNI template. This transformation was then applied to the co-registered SWI images and to the microhemorrhage coordinates. The frequencies of microhemorrhages were determined in major structures from ROIs defined in the digital Talairach brain atlas and in white matter tracts defined using a diffusion tensor imaging atlas. A total of 629 microhemorrhages were found with an average of 22±42 (range=1-179) in the 24 positive TBI patients. Microhemorrhages mostly congregated around the periphery of the brain and were fairly symmetrically distributed, although a number were found in the corpus callosum. From Talairach ROI analysis, microhemorrhages were most prevalent in the frontal lobes (65.1%). Restricting the analysis to WM tracts, microhemorrhages were primarily found in the corpus callosum (56.9%).

Original languageEnglish (US)
Title of host publicationMedical Imaging 2014
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
PublisherSPIE
ISBN (Print)9780819498311
DOIs
StatePublished - 2014
EventMedical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States
Duration: Feb 16 2014Feb 18 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9038
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego, CA
Period2/16/142/18/14

Keywords

  • Brain Atlas
  • MNI space
  • Microhemorrhages
  • Registration
  • SWI
  • Talairach ROI analysis
  • Traumatic Brain Injury

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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