Abstract
This study examines the spatial distribution of microhemorrhages defined using susceptibility weighted images (SWI) in 46 patients with Traumatic Brain Injury (TBI) and applying region of interest (ROI) analysis using a brain atlas. SWI and 3D T1-weighted images were acquired on a 3T clinical Siemens scanner. A neuroradiologist reviewed all SWI images and manually labeled all identified microhemorrhages. To characterize the spatial distribution of microhemorrhages in standard Montreal Neurological Institute (MNI) space, the T1-weighted images were nonlinearly registered to the MNI template. This transformation was then applied to the co-registered SWI images and to the microhemorrhage coordinates. The frequencies of microhemorrhages were determined in major structures from ROIs defined in the digital Talairach brain atlas and in white matter tracts defined using a diffusion tensor imaging atlas. A total of 629 microhemorrhages were found with an average of 22±42 (range=1-179) in the 24 positive TBI patients. Microhemorrhages mostly congregated around the periphery of the brain and were fairly symmetrically distributed, although a number were found in the corpus callosum. From Talairach ROI analysis, microhemorrhages were most prevalent in the frontal lobes (65.1%). Restricting the analysis to WM tracts, microhemorrhages were primarily found in the corpus callosum (56.9%).
| Original language | English (US) |
|---|---|
| Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Publisher | SPIE |
| Volume | 9038 |
| ISBN (Print) | 9780819498311 |
| DOIs | |
| State | Published - 2014 |
| Externally published | Yes |
| Event | Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, CA, United States Duration: Feb 16 2014 → Feb 18 2014 |
Other
| Other | Medical Imaging 2014: Biomedical Applications in Molecular, Structural, and Functional Imaging |
|---|---|
| Country | United States |
| City | San Diego, CA |
| Period | 2/16/14 → 2/18/14 |
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Keywords
- Brain Atlas
- Microhemorrhages
- MNI space
- Registration
- SWI
- Talairach ROI analysis
- Traumatic Brain Injury
ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Characterizing the spatial distribution of microhemorrhages resulting from Traumatic Brain Injury (TBI). / Li, Ningzhi; Chou, Yi Yu; Shiee, Navid; Chan, Leighton; Pham, Dzung L.; Butman, John A.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9038 SPIE, 2014. 90381Q.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Characterizing the spatial distribution of microhemorrhages resulting from Traumatic Brain Injury (TBI)
AU - Li, Ningzhi
AU - Chou, Yi Yu
AU - Shiee, Navid
AU - Chan, Leighton
AU - Pham, Dzung L.
AU - Butman, John A.
PY - 2014
Y1 - 2014
N2 - This study examines the spatial distribution of microhemorrhages defined using susceptibility weighted images (SWI) in 46 patients with Traumatic Brain Injury (TBI) and applying region of interest (ROI) analysis using a brain atlas. SWI and 3D T1-weighted images were acquired on a 3T clinical Siemens scanner. A neuroradiologist reviewed all SWI images and manually labeled all identified microhemorrhages. To characterize the spatial distribution of microhemorrhages in standard Montreal Neurological Institute (MNI) space, the T1-weighted images were nonlinearly registered to the MNI template. This transformation was then applied to the co-registered SWI images and to the microhemorrhage coordinates. The frequencies of microhemorrhages were determined in major structures from ROIs defined in the digital Talairach brain atlas and in white matter tracts defined using a diffusion tensor imaging atlas. A total of 629 microhemorrhages were found with an average of 22±42 (range=1-179) in the 24 positive TBI patients. Microhemorrhages mostly congregated around the periphery of the brain and were fairly symmetrically distributed, although a number were found in the corpus callosum. From Talairach ROI analysis, microhemorrhages were most prevalent in the frontal lobes (65.1%). Restricting the analysis to WM tracts, microhemorrhages were primarily found in the corpus callosum (56.9%).
AB - This study examines the spatial distribution of microhemorrhages defined using susceptibility weighted images (SWI) in 46 patients with Traumatic Brain Injury (TBI) and applying region of interest (ROI) analysis using a brain atlas. SWI and 3D T1-weighted images were acquired on a 3T clinical Siemens scanner. A neuroradiologist reviewed all SWI images and manually labeled all identified microhemorrhages. To characterize the spatial distribution of microhemorrhages in standard Montreal Neurological Institute (MNI) space, the T1-weighted images were nonlinearly registered to the MNI template. This transformation was then applied to the co-registered SWI images and to the microhemorrhage coordinates. The frequencies of microhemorrhages were determined in major structures from ROIs defined in the digital Talairach brain atlas and in white matter tracts defined using a diffusion tensor imaging atlas. A total of 629 microhemorrhages were found with an average of 22±42 (range=1-179) in the 24 positive TBI patients. Microhemorrhages mostly congregated around the periphery of the brain and were fairly symmetrically distributed, although a number were found in the corpus callosum. From Talairach ROI analysis, microhemorrhages were most prevalent in the frontal lobes (65.1%). Restricting the analysis to WM tracts, microhemorrhages were primarily found in the corpus callosum (56.9%).
KW - Brain Atlas
KW - Microhemorrhages
KW - MNI space
KW - Registration
KW - SWI
KW - Talairach ROI analysis
KW - Traumatic Brain Injury
UR - http://www.scopus.com/inward/record.url?scp=84901806085&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84901806085&partnerID=8YFLogxK
U2 - 10.1117/12.2043750
DO - 10.1117/12.2043750
M3 - Conference contribution
AN - SCOPUS:84901806085
SN - 9780819498311
VL - 9038
BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
PB - SPIE
ER -